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Fig. 5 | Respiratory Research

Fig. 5

From: Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

Fig. 5

Correlations of the pathways of interest with clinical parameters and T-cell subpopulations in BAL in female COPD patients. a) Correlation between the proteins in the lysosomal pathway and CT attenuation values <−950 HU in female COPD group (PLS inner relation, R2 = 0.81, p = 0.002). b) The correlation between the proteins in the regulation of actin cytoskeleton pathway and FEV1/FVC (PLS inner relation, R2 = 0.83, p = 0.002) in female COPD patients. c) The proteins in the FcγR-mediated phagocytosis pathway highly correlated with chemokine receptor CXCR4 on CD4+ T cells (R2 = 0.97, p < 0.0001). d) The proteins in the regulation of actin cytoskeleton pathway correlated with CXCR4-expressing on CD8+ T cells (R2 = 0.86, p = 0.001)

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