Skip to main content
Fig. 3 | Respiratory Research

Fig. 3

From: Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

Fig. 3

Multivariate OPLS-DA models comparing Smokers vs COPD groups before and after stratification by gender. OPLS-DA modeling showed significant separations between Smoker and COPD groups for a) joint gender (R2 = 0.85, Q2 = 0.66, p[CV-ANOVA] = 4.6 × 10−8, 116 proteins), b) females (R2 = 0.85, Q2 = 0.81; p = 1.9 × 10−7, 145 proteins) and d) males (R2 = 0.78, Q2 = 0.73, p = 9.4 × 10−6, 24 proteins). However, the predictive performances (Q2) were better following stratification by gender for both gender models. c) Loadings of the top 24 proteins out of 145 significant variables in the female COPD vs Smoker model; e) All 24 significant proteins from the male COPD vs Smokers model. There was no overlap among 24 top proteins of both gender models. A comprehensive list of loadings along with protein names and statistics are provided in Additional file 2: Table S2. f) Venn diagram displaying overlap between genders in protein alterations due to COPD based on the OPLS-DA models displayed in b) and d). Only four proteins (Q9NSE4, P02751, O95470, and P01876) were altered in both male and female smokers with COPD

Back to article page