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Fig. 2 | Respiratory Research

Fig. 2

From: Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

Fig. 2

a) The protein (Isochorismatase domain-containing protein 2, ISOC2, Uniprot: Q96AB3) exemplifies the profile of a protein that was identified as significantly altered in the joint gender analysis (p = 0.01), in spite of a high heterogeneity (I2 = 0.88). Stratification by gender revealed that this significance was completely driven by that of in female population (p = 0.0002), and was not altered in males (p = 0.66) b) Venn diagram showing the overlap in alterations of proteomic profiles between Smokers and COPD groups in joint gender and gender stratified univariate statistical analyses. Only three proteins were altered in both male and female COPD patients, and the majority of protein alterations in female patients were unique

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