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Fig. 5 | Respiratory Research

Fig. 5

From: Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model

Fig. 5

Role of p38 MAPK and oxidative stress in the ozonic effects on OVA challenged mice. OVA-O3 mice were received tail vein injection of SB239063 (4 mg/kg) (DMSO as control), or oral feeding of α-tocopherol (15 IU/kg) (50% ethanol as control), or both. a The lung function was assessed by the AHR in the left panels with the dose-response curves of Penh (top) and the log concentrations of methacholine required to increase Penh by 100% from baseline (LogPC100Penh) (bottom) showed, the airway resistance (top right) and the lung compliance (bottom right). b The total and differential cell counts in the BALF. c The representative images of H&E stained lung sections (top) and histological inflammation scores (bottom). d cytokines (IL-6, IL-13 and IFN-γ) and HA concentration in the BALF. e mRNAs expression of TNF-α, IL-5, IL-17 and CXCL-1 in the lungs. Data are shown as mean ± SEM; n = 7 in each group. Synergistic effect of SB239063& α-tocopherol, :p < 0.05

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