From: Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression
 | Nasal | Bronchial (cohort 1) | Bronchial (cohort 2) | |||
---|---|---|---|---|---|---|
 | t-value | p value‡ | t-value | FDR p value | t-value | p value‡ |
Enriched pathways for genes upregulated in COPD | ||||||
 O-glycan biosynthesis (KEGG) |  | 0.01# |  | <0.01# |  | 0.02# |
   GALNT6 | 3.00 | <0.01 | 3.21 | 0.02 | 1.57 | 0.13 |
   GALNT12 | 3.25 | <0.01 | 3.32 | 0.01 | 3.83 | <0.01 |
   B3GNT6 | 2.51 | 0.02 | 3.55 | <0.01 | 2.92 | <0.01 |
   ST6GALNAC1 | 2.65 | 0.01 | 3.44 | <0.01 | 1.91 | 0.07 |
 Glycosphingolipid biosynthesis (KEGG)a |  | 0.04# |  | <0.01# |  | 0.11# |
   FUT3 | 2.13 | 0.04 | 6.76 | <0.01 | 2.68 | 0.01 |
   FUT6 | 2.72 | 0.01 | 6.22 | <0.01 | 2.77 | 0.01 |
   B4GALT4 | 2.11 | 0.04 | 4.15 | <0.01 | 0.12 | 0.90 |
   B3GNT3 | 3.32 | <0.01 | 5.06 | <0.01 | 1.36 | 0.19 |
Enriched pathways for genes downregulated in COPD | ||||||
 DNA replication (KEGG) |  | <0.01# |  | 0.09# |  | 0.19# |
   RFC3 | −2.36 | 0.02 | −3.82 | <0.01 | −2.43 | 0.02 |
 RNA degradation (KEGG) |  | <0.01# |  | 0.06# |  | 0.06# |
 Propanoate metabolism (KEGG) |  | 0.13# |  | 0.20# |  | 0.09# |
   LDHB | −3.93 | <0.01 | −3.88 | <0.01 | −1.12 | 0.28 |
   ACADM | −2.71 | 0.01 | −6.06 | <0.01 | −2.14 | 0.04 |
   ALDH3A2 | −2.53 | 0.02 | −4.57 | <0.01 | −1.15 | 0.26 |
 Tight junction (KEGG) |  | 0.13# |  | 0.21# |  | 0.24# |
   CLDN16 | −2.33 | 0.02 | −3.56 | <0.01 | −2.76 | 0.01 |
   CTNNB1 | −3.33 | <0.01 | −3.18 | 0.02 | −1.65 | 0.11 |
   EPB41L2 | −2.64 | 0.01 | −6.03 | <0.01 | −1.67 | 0.11 |