Focal membrane thickening | Capillary congestion | Intra-alveolar hemorrhage | Interstitial neutrophil infiltration | Intra-alveolar neutrophil infiltration | Total lung injury score | |
---|---|---|---|---|---|---|
Ctr | 0.6 ± 0.16 | 0.3 ± 0.15 | 0.2 ± 0.13 | 0.1 ± 0.1 | 0 ± 0 | 1.2 ± 0.38 |
6 h IRB | 1.33 ± 0.16* | 1.22 ± 0.22* | 0.55 ± 0.17 | 0.88 ± 0.26* | 0.55 ± 0.17* | 4.55 ± 0.85* |
6 h IRB + Src Inh. | 1.16 ± 0.16 | 1 ± 0.25* | 0.33 ± 0.21 | 0.66 ± 0.33 | 0.33 ± 0.21 | 3.5 ± 0.99* |
6 h IRB + ERK Inh. | 0.85 ± 0.26 | 0.71 ± 0.18 | 0.57 ± 0.29 | 0.57 ± 0.29 | 0.42 ± 0.20 | 3.14 ± 1.01 |