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Table 2 Histological features of acute lung injury following inspiratory resistive breathing and the effect of Src and ERK inhibition

From: The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation

 

Focal membrane thickening

Capillary congestion

Intra-alveolar hemorrhage

Interstitial neutrophil infiltration

Intra-alveolar neutrophil infiltration

Total lung injury score

Ctr

0.6 ± 0.16

0.3 ± 0.15

0.2 ± 0.13

0.1 ± 0.1

0 ± 0

1.2 ± 0.38

6 h IRB

1.33 ± 0.16*

1.22 ± 0.22*

0.55 ± 0.17

0.88 ± 0.26*

0.55 ± 0.17*

4.55 ± 0.85*

6 h IRB + Src Inh.

1.16 ± 0.16

1 ± 0.25*

0.33 ± 0.21

0.66 ± 0.33

0.33 ± 0.21

3.5 ± 0.99*

6 h IRB + ERK Inh.

0.85 ± 0.26

0.71 ± 0.18

0.57 ± 0.29

0.57 ± 0.29

0.42 ± 0.20

3.14 ± 1.01

  1. Data presented as mean ± SEM, n = 6–10 per group. * p < 0.05 to ctr