Fig. 7From: The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammationThe effect of ERK inhibition on lung permeability and gravimetric parameters following 6 h IRB. a. ERK inhibition had a moderate effect on total protein level in BAL fluid, since although it remained significantly elevated to ctr, was also reduced compared to 6 h IRB. b. Pretreament with PD-98059 abolished the increase of evans blue dye extravasation in the lung at 6 h IRB, suggesting a protective effect of ERK inhibition on lung permeability. c. After ERK inhibition, the increase of wet lung weight to total body weight at 6 h IRB was blunted. Data presented as mean ± SEM, n = 13–16 per group for a, n = 4–8 per group for b, n = 10–11 per group for c. * p < 0.05 to ctr, # p < 0.05 to 6 h IRB, white bar, control, black bar, 6 h IRB, grey bar, 6 h IRB + ERK InhBack to article page