Fig. 6

The effect of ERK inhibition on pulmonary inflammation induced by 6 h of IRB. a. Pretreatment with PD98059 inhibited the increase in total cell number in BAL fluid after 6 h of IRB, by reducing both macrophages and neutrophils count. b. ERK inhibition also abolished the increase in lung tissue protein levels of IL-1 (left), while had no effect on the increased MIP-2a levels measured after 6 h of IRB (right). Data presented as mean ± SEM, n = 10–11 per group for A, n = 5–15 per group for B. * p < 0.05 to ctr, # p < 0.05 to 6 h IRB, white bar, control, black bar, 6 h IRB, grey bar, 6 h IRB + ERK Inh