Fig. 2

Effect of Src kinase inhibition on IRB-induced lung injury. a. Src inhibition attenuated the increase in BAL cellularity, by reducing the count of both macrophages and neutrophils, following 6 h of IRB. b. 6 h of IRB was followed by an increase in lung tissue levels of both IL-1β (left) and MIP-2a (right) relative to control, an effect that was not influenced by Src inhibition. c. PP-2 administration prior to IRB did not alter the increase in lung permeability, as assessed by total protein levels in BAL fluid. d. Wet lung to total body weight, an index of pulmonary edema, was increased after 6 h of IRB, a finding not affected by PP-2 administration. Data presented as mean ± SEM, n = 5–16 per group, *p < 0.05 to ctr, #p < 0.05 to 6 h IRB, white bars, control, black bars, 6 h IRB, dark grey bars, 6 h IRB + Src Inh