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Table 2 Immunohistochemical staining profile of solitary fibrous tumors of the pleura

From: Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score – a multicenter study

Staining All (n = 78) Adverse outcome (n = 9) Favorable outcome (n = 69) p-value*
CD34, n (%)     0.6
 0 0 (0) 0 (0) 0 (0)
 1 11 (14.1) 2 (22.2) 9 (13.0)
 2 27 (34.6) 2 (22.2) 25 (36.2)
 3 40 (51.3) 5 (55.6) 35 (50.7)
Bcl-2, n (%)     0.2
 0 0 (0) 0 (0) 0 (0)
 1 25 (32.1) 3 (33.3) 22 (31.9)
 2 27 (34.6) 1 (11.1) 26 (37.7)
 3 26 (33.3) 5 (55.6) 21 (30.4)
Vimentin, n (%)     n/a
 0 0 (0)   
 1 0 (0)   
 2 0 (0)   
 3 78 (100)   
NAB-STAT6, n (%)     0.86
 0 3 (3.8) 2 (22.2) 1 (1.4)
 1 24 (30.8) 1 (11.1) 23 (33.3)
 2 35 (44.9) 3 (33.3) 32 (46.4)
 3 16 (20.5) 3 (33.3) 13 (18.8)
p53, n (%)     0.13
 0 3 (3.9) 0 (0) 3 (4.5)
 1 40 (52.6) 4 (44.4) 36 (53.7)
 2 28 (36.8) 2 (22.2) 26 (38.8)
 3 5 (6.6) 3 (33.3) 2 (3)
IGF2, n (%)     n/a
 0 0 (0)   
 1 0 (0)   
 2 0 (0)   
 3 78 (100)   
CD99, n (%)     0.6
 0 4 (5.1) 1 (11.1) 3 (4.3)
 1 39 (50.0) 5 (55.6) 34 (49.3)
 2 22 (28.2) 1 (11.1) 21 (30.4)
 3 13 (16.7) 2 (22.2) 11 (15.9)
MIB-1 proliferation index (Ki-67), median % (IQR) 1 (1.0–3.0) 10 (1–17) 1.0 (1.0–2.5) 0.044
MIB-1 proliferation index (Ki-67) ≥ 10%, n (%) 5 (6.4) 5 (55.6) 0 (0) < 0.001
  1. The stainings were classified as negative (0), weak (1), intermediate (2) and strong (3)
  2. HPF high-power field, n/a not applicable
  3. *Chi-square test or Mann-Whitney U-test as appropriate