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Table 1 Clinicopathological characteristics of all subjects studied

From: Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis

Characteristics

Controls

IPF

RA-ILD

p value

Number

10

59

27

 

Age

56.6 ± 8.6

64.17 ± 10.41

63.3 ± 10

C vs IPF vs RA-ILD ns*

Gender (male/female)

10/0

45/14

15/12

C vs IPF ns**

IPF vs RA-ILD ns

p < 0.05 C vs RA-ILD

Non-smokers vs ever-smokers

10/0

36/23

14/13

C vs IPF vs RA-ILD ns**

Py

49.6 ± 8

30.9 ± 21

43.3 ± 43

p < 0.01 C > IPF***

RA-ILD vs IPF vs C ns

P < 0.01 C > IPF*

FEV1% pred

 

76.82 ± 17.09

80.9 ± 22

RA-ILD vs IPF*

FVC % pred

 

73.9 ± 18.08

81.1 ± 24.7

RA-ILD vs IPF ns*

DLco % pred

 

43.45 ± 13.4

51.9 ± 14.3

P < 0.05 IPF < RA***

CPI (units)

 

50.69 ± 13.02

42.6 ± 15.5

P < 0.01 IPF > RA*

Macrophages(%)

77.7 ± 13

76.37 ± 11.45

65,1 ± 20.55

C vs RA-ILD vs IPF Ns*

Lymphocytes(%)

18.7 ± 10

9.9 ± 7.9

25.5 ± 20.3

p < 0.001 IPF < RA-ILD*C vs RA vs IPF ns

Polymorphonuclear(%)

1.3 ± 1.5

10.9 ± 11.5

7.8 ± 4.9

C vs IPF vs RA-ILD ns*

Eosinophils (%)

0

4.6 ± 5

2.5 ± 1.8

C vs IPF vs RA-ILD ns*

  1. Values are expressed as means ± standard deviations
  2. *Ordinary one-way ANOVA; P < 0.05, following bonferroni adjustment, is considered statistically significant
  3. **χ2 test; P < 0.05, following Bonferroni adjustment, is considered statistically significant
  4. ***Kruskal-Wallis test, P < 0,05, following Dunn’s adjustment is considered statistically significant
  5. Abbreviations: FEV1: forced expiratory volume in one second, FVC: forced vital capacity, DLCO: diffusing capacity for carbon monoxide, C: controls, py: packet years