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Fig. 7 | Respiratory Research

Fig. 7

From: TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/β-catenin signaling

Fig. 7

Summary of the main findings. a Steady-state: cytosolic β-catenin is phosphorylated by the GSK complex and targeted to the proteasome for degradation. b Wnt ligand production after TGF-β exposure stabilize GSK complex at the cell membrane and reduce β-catenin degradation. c Then, the massive relocation of β-catenin after poly(I:C) treatment, fuels the Wnt/β-catenin pathway and allows β-catenin translocation in the nucleus for MMP-9 expression

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Respiratory Research

ISSN: 1465-993X

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