|
ICS/FABA regimen vs. FABA regimen
|
|
All
|
2 [17, 30]
|
−0.290
|
[−0.490, −0.090]
|
0.004
|
8.7
|
0.96
|
4 [17, 27, 29, 30]
|
0.083
|
[−0.074, 0.240]
|
0.303
|
22.9
|
0.94
|
|
Adult
|
1 [17]
|
−0.207
|
[−0.461, 0.047]
|
0.110
|
–
|
0.48
|
2 [17, 27]
|
0.068
|
[−0.147, 0.284]
|
0.534
|
0.0
|
0.16
|
|
Children and adolescent
|
1 [30]
|
−0.427
|
[−0.752, −0.102]
|
0.010
|
–
|
0.82
|
2 [29, 30]
|
0.099
|
[−0.131, 0.329]
|
0.398
|
71.0
|
0.94
|
|
ICS/FABA regimen vs. ICS regimen
|
|
All
|
2 [17, 30]
|
−0.098
|
[−0.284, 0.087]
|
0.299
|
0.0
|
0.57
|
4 [17, 26, 29, 30]
|
−0.253
|
[−0.373, −0.132]
|
<0.001
|
0.0
|
0.81
|
|
Adult
|
1 [17]
|
−0.026
|
[−0.286, 0.234]
|
0.845
|
–
|
0.07
|
1 [17]
|
−0.160
|
[−0.421, 0.100]
|
0.228
|
–
|
0.32
|
|
Children and adolescent
|
1 [30]
|
−0.173
|
[−0.438, 0.091]
|
0.200
|
–
|
0.36
|
3 [26, 29, 30]
|
−0.278
|
[−0.414, −0.142]
|
<0.001
|
0.0
|
0.66
|
|
ICS regimen vs. FABA regimen
|
|
All
|
2 [17, 30]
|
−0.261
|
[−0.465, −0.056]
|
0.012
|
0.0
|
0.96
|
3 [17, 29, 30]
|
0.275
|
[0.102, 0.448]
|
0.002
|
0.0
|
1.00
|
|
Adult
|
1 [17]
|
−0.212
|
[−0.475, 0.051]
|
0.115
|
–
|
0.47
|
1 [17]
|
0.249
|
[−0.015, 0.512]
|
0.064
|
–
|
0.56
|
|
Children and adolescent
|
1 [30]
|
−0.335
|
[−0.658, −0.011]
|
0.043
|
–
|
0.64
|
2 [29, 30]
|
0.295
|
[0.065, 0.525]
|
0.012
|
40.8
|
0.99
|
|
Comparisons
|
Rescue medication required per day
|
FEV1% of predicted value
|
|
No. of Studies
|
SMD
|
95% CI
|
P value
|
I2-squared (%)
|
Power
|
No. of Studies
|
SMD
|
95% CI
|
P value
|
I2-squared (%)
|
Power
|
|
ICS/FABA regimen vs. FABA regimen
|
|
All
|
5 [17, 27,28,29,30]
|
−0.138
|
[−0.290, 0.014]
|
0.076
|
18.0
|
0.98
|
3 [17, 27, 29]
|
0.773
|
[0.105, 1.441]
|
0.023
|
91.3
|
1.00
|
|
Adult
|
3 [17, 27, 28]
|
−0.226
|
[−0.429, −0.023]
|
0.029
|
0.0
|
0.52
|
2 [17, 27]
|
0.405
|
[0.188, 0.623]
|
<0.001
|
0.0
|
0.94
|
|
Children and adolescent
|
2 [29, 30]
|
−0.025
|
[−0.254, 0.205]
|
0.834
|
46.0
|
0.34
|
1 [29]
|
1.429
|
[1.064, 1.794]
|
<0.001
|
–
|
1.00
|
|
ICS/FABA regimen vs. ICS regimen
|
|
All
|
5 [17, 26, 28,29,30]
|
0.192
|
[0.075, 0.309]
|
0.001
|
16.2
|
1.00
|
2 [17, 29]
|
−0.061
|
[−0.629, 0.506]
|
0.832
|
86.3
|
0.96
|
|
Adult
|
2 [17, 28]
|
0.097
|
[−0.141, 0.335]
|
0.424
|
0.0
|
0.20
|
1 [17]
|
0.219
|
[−0.042, 0.480]
|
0.100
|
–
|
0.50
|
|
Children and adolescent
|
3 [26, 29, 30]
|
0.222
|
[0.088, 0.356]
|
0.001
|
49.5
|
0.91
|
1 [29]
|
−0.360
|
[−0.691, −0.030]
|
0.033
|
–
|
0.68
|
|
ICS regimen vs. FABA regimen
|
|
All
|
4 [17, 28,29,30]
|
−0.152
|
[−0.318, 0.014]
|
0.073
|
0.0
|
0.87
|
2 [17, 29]
|
0.415
|
[−0.102, 0.933]
|
0.001
|
83.2
|
1.00
|
|
Adult
|
2 [17, 28]
|
−0.227
|
[−0.468, 0.014]
|
0.065
|
0.0
|
0.56
|
1 [17]
|
0.161
|
[−0.101, 0.424]
|
0.229
|
–
|
0.33
|
|
Children and adolescent
|
2 [29, 30]
|
−0.084
|
[−0.313, 0.014]
|
0.471
|
55.1
|
0.53
|
1 [29]
|
0.690
|
[0.356, 1.024]
|
<0.001
|
–
|
0.99
|
