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Fig. 5 | Respiratory Research

Fig. 5

From: A 3D epithelial–mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-β1 treatment

Fig. 5

Increased expression of extracellular matrix-related genes following TGF-β1 stimulation in co-culture model on culture day 21. Expression levels of 84 genes were analyzed using PCR; 33 significantly upregulated genes are presented in the graphs. a TGF-β1 and integrins; b tissue inhibitors of matrix metalloproteinase (TIMPs) and matrix metalloproteinases (MMPs); c adhesion molecules; d collagens; e extracellular matrix glycoproteins and proteoglycans. All data are shown as means ±95% confidence intervals of triplicate inserts. *p < 0.05 (Student’s t-test against the control)

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