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Fig. 3 | Respiratory Research

Fig. 3

From: Roles of Bronchopulmonary C-fibers in airway Hyperresponsiveness and airway remodeling induced by house dust mite

Fig. 3

Effects of degeneration of pulmonary C-fibers (PCFs) on the house dust mite (HDM)-induced airway smooth muscle (ASM) proliferation. a Immunofluorescence for α-SMA (red) in the airways (scale bars = 50 μm). Images are the micrographs showing the representative α-SMA immunoreactivity in a CtrlIntact, HDMIntact, CtrlPCFX, and HDMPCFX mice, respectively. b Quantification of α-SMA in the airways. The thickness of airway smooth muscle layer was expressed as the ratio of α-SMA positive area to the length of the subepithelial basement membrane. Data are presented as mean ± SEM. Numbers of mice were five in each group. c α-SMA quantified by western blot and normalized to GAPDH levels. Numbers of mice were five in each group; * and ** P < 0.05 and 0.01, HDMIntact versus CtrlIntact group; ^ and ^^ P < 0.05 and 0.01, HDMPCFX versus HDMIntact group

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