Fig. 1

Effects of degeneration of pulmonary C-fibers (PCFs) on the house dust mite (HDM)-induced airway hyperresponsiveness (AHR). Airway resistance (sRaw) was measured during exposure to aerosolized saline (0 mg/ml) and methacholine solutions in a dose-increasing manner. Numbers of mice were 12, 12, 9, and 9 for Ctrl_Intact, HDM_Intact, Ctrl_PCFX, and HDM_PCFX respectively. Data are presented as mean ± SEM. ** P < 0.01, HDM_Intact versus Ctrl_Intact group. # and ## P < 0.05 and 0.01, HDM_PCFX versus Ctrl_PCFX group. ^ and ^^, P < 0.05 and 0.01, HDM_PCFX versus HDM_Intact group