Fig. 1From: The potential of interleukin-37 as an effective therapeutic agent in asthmaIL-37 binding and signal transduction. IL-37 binds to IL-18Rα instead of IL-18 and recruits the orphan decoy IL-1R8, which leads to suppression of innate and acquired immunity, as well as augmentation of anti-inflammatory pathway, instead of activation of the IL-18 pathway. Adapted from Novick (2013) [61] and Dinarello (2016) [62]Back to article page