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Table 1 Overview of studies in human CDH

From: Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy

Our group

Others

Increased expression of ETA and ETB (protein level)

- Increased ET-1 (plasma levels and protein level) -[43]

Increased expression of ECE-1 (protein level)

- Increased ET-1 (plasma levels) [9]

- Increased expression of ETA and ETB (RNA and protein level) [6]

No differences in eNOS expression [16]

- Increased expression of eNOS in arteriolar endothelium and alveolar epithelium (protein level) [17]

- No differences in eNOS expression (protein level) [19]

- Decreased expression of eNOS (protein and RNA level) [14]

Decreased expression of Ptgir (protein level)

- No information about prostaglandin I2