Table 3 Upstream Regulators of the genes listed in our dataset (target genes, Additional file 3: Table E2 and Additional file 4: Table E3) as predicted by IPA analysis

Cytokine

 TNF

2.86 10 ⁻⁴

APOA1, BST2, C3, CCL2, CH25H, CIDEC, COL4A3, CPT1B, CXCL1, CXCL8, CYP1A1, CYP1B1, DLX1, EHF, FGF10, HES1, ICAM1, IL32, IL6, KL, KYNU, LGALS9B, NFKBIA, NFKBIZ, RELB, SLC1A3, SQSTM1, VDR, ZC3H12A (29)

 IL1B

2.61 10 ⁻³

C1R, C3, CCL2, CXCL1, CXCL8, CYP1A1, EHF, HES1, ICAM1, IL32, IL6, LGALS9B, NFKBIA, NFKBIZ, RELB, SLC1A3, VDR, ZC3H12A (18)

 OSM

7.71 10 ⁻³

C1R, CCL2, CH25H, CXCL1, CXCL8, CYP1B1, ICAM1, IL32, IL6, SLC16A6, VDR (11)

ERBB3

 IL6

1.15 10 ⁻²

APOA1, BST2, C3, CCL2, CXCL1, CXCL8, CYP1A1, CYP1B1, ICAM1, IL6, NFKBIA, USP17L1 (12)

TNFRSF25, TLR1

Signaling

 NFkB (complex)

1.20 10 ⁻³

BEX2, C1R, C3, CCL2, CXCL1, CXCL8, EHF, ICAM1, IL32, IL6, KYNU, NFKBIA, NFKBIZ, RELB, ZC3H12A (15)

 MYD88

3.31 10 ⁻⁷

C3, CCL2, CH25H, CXCL1, CXCL8, FGF10, ICAM1, IL32, IL6, NFKBIA, NFKBIZ, RELB, ZC3H12A (13)

PILRA

 Akt (group)

1.00 10 ⁻²

CCL2, CXCL8, HES, IL32, IL6, KL

ERBB3

 ERK (group)

9.60 10 ⁻³

CCL2, CXCL8, CYP1A1, ICAM1, IL6, KYNU, NFKBIZ

Transcription Factor

 JUN

1.08 10 ⁻⁴

CCL2, CXCL1, CXCL8, CYP1B1, HES1, ICAM1, IL6, NFKBIA, NFKBIZ, PARD6B, RELB, VDR (12)

MBP, PAK3,

 RELA

3.55 10 ⁻⁵

BEX2, C3, CCL2, CXCL1, CXCL8, CYP1A1, EHF, FGF10, HES1, ICAM1, IL32, IL6, NFKBIA, RELB (14)

 STAT1

3.05 10⁻²

C3, CCL2, CH25H, CXCL8, HES, ICAM1, IL6

 STAT3

1.67 10⁻²

BEX2, BST2, CCL2, CXCL8, ICAM1, IL12RB1, IL6, NFKBIZ, SLC1A3, VDR

EGR3