Table 1 Demographics, clinical and functional characteristics of patients

Number of subjects

Age, yrs

59.8 (10.5)

65.6 (10.1)

0.007

Gender (% female)

59.1

18.5

<0.001

BMI (Kg/m²)

28.2 (5.2)

28.8 (6.5)

0.91

Pack/yrs^b

35.1 (13.2)

51.8 (28)

<0.001

Age of onset (yrs)

48.5 (19.1)

53.6 (12.3)

<0.001

SPT^c (%)

45.5

23.1

0.003

Rhinitis (%)

51.2

17.5

0.001

Patients with nocturnal symptoms (%)

39.5

9.5

0.001

Comorbidities:

38.6

47.7

0.36

-Arterial hypertension (%)

-Diabetes (%)

9.1

23.1

0.26

-Ischemic heart disease (%)

4.5

4.6

0.11

-Heart failure (%)

1.0

7.7

0.26

-Anemia (%)

0

1.5

0.58

-Osteoporosis (%)

18.6

3.2

0.002

-Psychiatric disorders (8%)

18.2

4.6

0.15

-Gastro-esophageal Reflux (%)

35.7

12.7

<0.001

Prebd FEV1^d (%)

59.0 (18.3)

50.3 (14.3)

<0.001

Posbd FEV1^e(%)

65.5 (17.5)

54.5 (15.2)

0.001

PBT^f (%)

48.8

30.2

0.001

DLCO^g (%)

70.0 (17.6)

64.0 (19.9)

<0.001

Exacerbations^h

1.00 (1.3)

0.95 (1.3)

0.62

IgE (IU/ml)

112 (4, 1340)

76 (5,2500)

0.005

CATⁱ

13.2 (8.0)

13.4 (7.7)

0.83

ACT^j

19.5 (4.9)

19.2 (4.8)

0.54