Table 1 Demographics of subjects
From: The value of blood cytokines and chemokines in assessing COPD
|  | Never smokers N = 25 | COPDGene N = 2098 | SPIROMICS N = 1117 | p-value (SPIROMICS vs COPDGene) (current and former smokers) |
|---|---|---|---|---|
Age (years) | 57.5 (7) | 65.8 (8.9) | 62.7 (9) | < 10−04 |
Gender Male | 36.0% | 50.9% | 51.9% | 0.6931 |
Race | ||||
 White | 100.0% | 71.2% | 74.9% |  |
 Black | 0.0% | 28.4% | 20.8% |  |
 Other | 0.0% | 0.0% | 4.3% |  |
Current Smoker | 0% | 34.7% | 40.5% | 0.0009 |
BMI (kg/m2) | 25.7 (4.2) | 28.8 (6.3) | 28.2 (5.4) | 0.0028 |
ATS Smoking, pack-years | 0 (0) | 45.1 (24) | 47.6 (24.7) | 0.0054 |
FEV1 (% predicted) | 105.5 (12) | 76.1 (25.6) | 76.1 (28.7) | 0.9906 |
FEV1/FVC | 0.8 (0) | 0.7 (0.2) | 0.6 (0.2) | < 10−04 |
BODE Index | 0.2 (0.4) | 1.3 (1.7) | 1.5 (2) | 0.0084 |
SGRQ | 2.7 (3.5) | 23.6 (21.1) | 32 (21.2) | < 10−04 |
Emphysema (% LAA < −950 HU) | 1 (1.3) | 6.5 (10.2) | 7.3 (10.4) | 0.0386 |
Chronic Bronchitis (%) | 4% | 15.2% | 20.9% | < 10−04 |
Duration of participation in study (years) | NA | 6.7 (1.2) | 2.2 (0.9) | < 10−04 |
Decline in FEV1 (ml/year) | NA | −38.1 (53.4) | −48.5 (144.1) | 0.0416 |
Exacerbations (#/year) | 0 (0) | 0.3 (0.8) | 0.5 (1.0) | < 10−04 |
Never Smoker | 100% | 0% | 0% | Â |
Spirometry category | ||||
 PRISm | 0% | 10.4% | 0% |  |
 Control Smoker | 0% | 41.5% | 49.3% |  |
 GOLD 1 | 0% | 9.3% | 7.9% |  |
 GOLD 2 | 0% | 20.4% | 17.5% |  |
 GOLD 3 | 0% | 12.2% | 18.1% |  |
 GOLD 4 | 0% | 5.8% | 7.1% |  |