Table 1 Comparison of patient characteristics of the analysis population
From: Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
Total 2645 | 1 AATD + T (110) | 2 AATD-T (29) | 3 COPD (2506) | Diff. between means (CI95%) p-value | |
|---|---|---|---|---|---|
Male sex | 1572 (59.4%) | 67 (60.9%) | 10 (34.5%) | 1495 (59.7%) | 1 vs. 3: 1.05 (0.71 1.56) 0.791 ~ 2 vs. 3: 0.36 (0.16 0.77) < .01 |
Age (years) | 65.00 (64.67–65.33) | 59.47 (57.88–61.07) | 61.28 (58.18–64.38) | 65.29 (64.95–65.62) | 1–2: −1.80 (−5.28–5.29) 0.310 1–3: −5.81 (−7.44–4.19) < .0001 2–3: −4.02 (−7.13–0.90) 0.012 |
COPD duration (years) | 7.80 (7.53–8.06) | 11.24 (9.95–12.53) | 9.57 (7.02–12.13) | 7.63 (7.35–7.90) | 1–2: 1.67 (−1.19 4.52) 0.254 1–3: 3.61 (2.29 4.92) < .0001 2–3: 1.95 (−0.63 4.51) 0.138 |
Weight (kg) | 78.91 (78.22–79.59) | 75.11 (71.75–78.47) | 74.28 (67.73–80.83) | 79.13 (78.43–79.83) | 1–2: 0.83 (−6.53 8.19) 0.824 1–3: −4.02 (−7.46–0.59)0.022 2–3: −4.86 (−11.5 1.73) 0.149 |
BMI | 26.97 (26.76–27.17) | 24.59 (23.59–25.59) | 24.76 (22.81–26.71) | 27.10 (26.89–27.31) | 1–2: −0.17 (−2.36 2.02) 0.881 1–3: −2.51 (−3.53–1.48) < .0001 2–3: −2.34 (−4,30–038) 0.019 |
Packyears | 44.31 (42.91–45.72) | 16.3 (9.54–23.04) | 11.8 (−1.37 24.91) | 45.9 (44.52–47.35) | 1–2: 4.52 (−10.26 19.29) 0.549 1–3: −29.6 (−36.54–22.75) < .0001 2–3: −34.16 (−47.38–20.94) < .0001 |
SGRQ Score | 43.05 (42.28–43.81) | 45.86 (42.13–49.59) | 34.45 (27.18–41.71) | 43.02 (42.24–43.81) | 1–2: 11.41 (3.25 19.58) 0.006 1–3: 2.82 (−099 6.62) 0.148 2–3: −8.59 (−15.90–1.29) 0.021 |
CAT | 18.00 (17.72–18.28) | 18.79 (17.41–20.17) | 16.59 (13.92–19.25) | 18.15 (17.86–18.44) | 1–2: 2.20 (−0.80 5.20) 0.151 1–3: 0.63 (−0.78 2.04) 0.382 2–3: −1.57 (−4.25 1.11) 0.251 |
EQ5D | 0.82 (0.81–0.83) | 0.83 (0.79–0.87) | 0.87 (0.80–0.95) | 0.82 (0.81–0.82) | 1–2: −0.04 (−0.13 0.04) 0.324 1–3: 0.01 (−0.03 0.06) 0.488 2–3: 0.06 (−0.02 0.13) 0.142 |
6-min-walk distance (m) | 419.29 (415.10–423.48) | 421.86 (400.99–442.74) | 495.96 (455.92–536.01) | 418.30 (414.01–422.59) | 1–2: −74.1 (−119.3–28.9) 0.001 1–3: 3.6 (−17.7 24.9) 0.736 2–3: 77.7 (37.5118.0) 0.0002 |
Time-up-and-go (seconds) | 6.99 (6.90–7.08) | 6.22 (5.76–6.689 | 6.44 (5.53–7.34) | 7.03 (6.93–7.12) | 1–2: −0.21 (−1.23 0.80) 0.681 1–3: −0.81 (−1.27–0.34) < .001 2–3: −0.59 (−1.51 0.32) 0.204 |
BODE Score | 2.29 (2.21–2.37) | 2.90 (2.52–3.29) | 1.29 (0.55–2.02) | 2.27 (2.19–2.35) | 1–2: 1.62 (0.79 2.45) < .001 1–3: 0.63 (0.23 1.02) < .01 2–3: −0.99 (−1.73–0.25) < .01 |