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Fig. 7 | Respiratory Research

Fig. 7

From: RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection

Fig. 7

Antiviral and cytokine responses in BALF were restored in RIG-I TG mice during influenza infection. For CS groups, RIG-I WT and TG mice were exposed to CS for 6 weeks in a smoke exposure chamber. Mice were intranasally infected with a non-lethal dose (300 pfu/mouse) of the IAV PR8. BALF was harvested at the indicated time points after infection. Mock treated mice were inoculated with PBS. a Th1 and b Th2 cytokine protein levels in the BALF were determined by multiplex immunoassay. Data are expressed as mean ± SEM (n = 6 per group). * denotes a significant difference compared to the WT CS PR8 group (P < 0.05)

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