Fig. 2From: RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infectionRIG-I overexpression improved survival and reduced weight loss due to CS exposure in IAV infection. a and b WT and littermate RIG-I TG mice were intranasally inoculated with a lethal dose of IAV (2000 pfu/mouse) without CS exposure. c and d WT and littermate RIG-I TG mice were exposed to CS or not for 6 weeks in a smoke exposure chamber (Teague Enterprises), then CS-exposed mice and NS WT mice were intranasally inoculated with a lethal dose of IAV (1000 pfu/mouse). Mortality (a and c) and body weights (b and d) were monitored daily. Body weight data were normalized to each mouse’s starting body weight. Data are expressed as mean ± standard deviation. * denotes a significant difference between the two groups by Kaplan-Meier survival test (P < 0.05)Back to article page