Diagnosed CTD-ILD (N = 42) | Non-CTD-ILD (N = 563) | P-value | |
---|---|---|---|
Age (mean ± SD) | 61.0 ± 11.0 | 67.0 ± 11.5 | 0.001 |
Sex | |||
Male, N(%) | 23 (54.8) | 337 (59.9) | 0.760 |
Female, N(%) | 19 (45.2) | 226 (40.1) | |
Smoking | |||
Nonsmoker, N(%) | 21 (50) | 219 (38.9) | 0.002 |
Ex-smoker, N(%) | 19 (45.2) | 334 (59.3) | |
Active smoker, N(%) | 2 (4.8) | 10 (1.8) | |
ROS positive, N(%) | 39 (92.9) | 89 (15.8) | <0.001 |
Positive serology | 41(97.6) | 172 (30.6) | <0.001 |
TLC% (mean ± SD) | 71.5 ± 17.1 | 72.7 ± 16.7 | 0.471 |
FVC%(mean ± SD) | 67.5 ± 16.3 | 69.0 ± 19.0 | 0.278 |
DLCO% (mean ± SD) | 49.0 ± 17.8 | 51.8 ± 16.1 | 0.315 |
Frequency of selected positive serology tests, N(%) | |||
ANA | 29 (69) | 82 (14.6) | <0.001 |
RF | 13 (31) | 38 (6.7) | <0.001 |
SS-A/SS-B | 16 (38.1) | 22 (3.9) | <0.001 |
Anti CCP | 7 (16.7) | 10 (1.8) | <0.001 |
Scl-70 | 6 (14.3) | 4 (0.71) | <0.001 |
Anti Jo | 3 (7.1) | 1 (0.17) | <0.001 |
RNP | 3 (7.1) | 21 (3.7) | 0.274 |
Positive clinical signs or symptoms, N (%) | |||
Raynaud’s phenomenon | 16 (38) | 15 (2.6) | <0.0001 |
Sicca symptoms | 7 (16.6) | 24 (4.2) | 0.0004 |
Arthralgias/synovitis | 19 (45) | 44 (7.8) | <0.0001 |
Rash/photosensitivity | 4 (9.5) | 19 (3.4) | 0.04 |
Myalgia/weakness | 7 (16.6) | 14 (2.5) | <0.0001 |
Mechanic hands | 2 (4.8) | 1 (0.1) | <0.0001 |
Gottron papules | 1 (2.3) | 0 (0) | 0.0002 |
Dysphagia | 5 (11.9) | 7 (1.2) | <0.0001 |
Fatigue/malaise/fever | 4 (9.5) | 8 (1.4) | 0.0003 |