Fig. 1
From: IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD
High levels of sputum IFNγ are associated with high levels of IL-18, IL-1α or IL-1β. a The concentrations of IL-18, IL-1α and IL1β in 35 sputum samples from patients either stable, having an exacerbation or convalescent were determined using the human MAPv1.6 multiplex assay. Results are colored by patient ID, and the data were fitted with a linear mixed effects model to account for patient variability and test for significant difference in exacerbation compared to stable or convalescence samples (see Additional file 1: Table S3). b Patients were grouped according to the median value at exacerbation of IL-18, IL-1α and IL-1β and the corresponding sputum IFNγ values were plotted. Lines indicate median. Statistical significance was assessed using a Student’s t-Test.