Table 4 Candidate genes for total lung capacity (TLC) in mice identified through the expression quantitative trait loci (e-QTL) strategy comparing C3H/HeJ (C3H) and JF1/MsJ (JF1). [cut off for fold change ≥2.0 fold at least in one stage among embryonic stage 18, postnatal stage (P) 28 and P70; false discovery rate = 0.10]
Trait | QTL Region | QTL Location (Basepair) | Gene Description | Gene symbol/location (basepair) | EntrezID | Fold Difference | ||
|---|---|---|---|---|---|---|---|---|
E18 | P28 | P70 | ||||||
Lfnq3 Chromosome: 15 | ||||||||
TLC, TLC/Bw | D15Mit85 to D15Mit105 | 40,313,626–72,500,731 | Leucine rich repeat containing 6 (testis) | Lrrc6 (66379858–66,500,910) | 54,562 | −2.03 | ns | ns |
Lfnq4 Chromosome: 17 | ||||||||
TLC | D17Mit156 to D17Mit234 | 10,987,597–39,053,168 | Radial spoke head 1 homolog (Chlamydomonas) | Rsph1 (31255019–31,277,356) | 22,092 | ns | 2.81 | 2.63 |
Formyl peptide receptor 1 | Fpr1 (17876471–17,883,939) | 14,293 | −2.05 | −1.75 | −2.26 | |||
ATP-binding cassette, sub-family G (WHITE), member 1 | Abcg1 (31057694–31,117,984) | 11,307 | ns | −1.76 | −2.44 | |||
Surfactant associated 2 | Sfta2 (35649708–35,650,569) | 433,102 | −4.02 | −2.19 | −2.23 | |||
Histocompatibility 2, class II antigen E beta | H2-Eb1 (34305867–34,316,674) | 14,969 | ns | −2.23 | −2.21 | |||
Histocompatibility 2, D region locus 1 | H2-D1 (35263094–35,267,497) | 14,964 | ns | 2.21 | 2.11 | |||
Histocompatibility 2, Q region locus 4 | H2-Q4 (35379555–35,384,674) | 15,015 | −1.52 | −3.19 | −2.86 | |||
Gamma-aminobutyric acid (GABA) B receptor, 1 | Gabbr1 (37045966–37,074,305) | 54,393 | −2.20 | −1.68 | −1.62 | |||