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Table 4 Association of QoL and therapy for IPF

From: Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

  N (%) mean (SD) Delta 95% CI p value mean (SD) Delta 95% CI p value mean (SD) Delta 95% CI p value mean (SD) Delta 95% CI p value
Antiinflammatory therapya
 No 426 (57.8%) 63.6 (19.0) (ref) 14.9 (5.9) (ref) 43.9 (19.9) (ref) 40.0 (27.9) (ref)
 Yes 311 (42.2%) 55.4 (19.7) −8.25
(−11.35; −5.15)
<0.001
12.6 (6.0) −2.22
(−3.18; −1.25)
<0.001
53.7 (20.4) 9.84
(6.54; 13.13)
<0.001
57.6 (32.3) 17.55
(11.47; 23.62)
<0.001
Antifibrotic therapy
 No 372 (50.5%) 59.7 (20.9) (ref) 14.0 (5.9) (ref) 46.8 (21.7) (ref) 46.2 (32.0) (ref)
 Yes 365 (49.5%) 60.3 (18.4) 0.63
(−2.48; 3.74)
0.691
13.8 (6.2) −0.19
(−1.17; 0.78)
0.698
49.9 (19.4) 3.05
(−0.29; 6.38)
0.074
49.4 (30.3) 3.13
(−3.04; 9.31)
0.319
Long-term oxygen therapy
 No 503 (68.3%) 65.8 (17.9) (ref) 15.2 (5.7) (ref) 42.0 (19.2) (ref) 36.4 (27.3) (ref)
 Yes 234 (31.8%) 47.8 (17.9) −17.93
(−20.96; −14.90)
<0.001
11.1 (5.7) −4.15
(−5.14; −3.17)
<0.001
61.2 (17.3) 19.18
(16.08; 22.28)
<0.001
71.2 (24.9) 34.83
(29.40; 40.25)
<0.001
Other non-pharmacological therapyb
 No 721 (97.8%) 60.3 (19.7) (ref) 14.0 (6.0) (ref) 48.1 (20.6) (ref) 47.5 (31.1) (ref)
 Yes 16 (2.2%) 49.4 (19.1) −10.86
(−20.35; −1.37)
0.025
10.3 (6.4) −3.71
(−6.87; −0.54)
0.022
56.3 (23.0) 8.24
(−3.55; 20.04)
0.17
66.4 (30.5) 18.98
(−2.30; 40.25)
0.08
Pulmonary rehabilitation
 Unknown 219 (30.3%) 57.7 (20.5) −4.04
(−7.57; −0.50)
0.025
13.5 (6.3) −0.69
(−1.80; 0.42)
0.222
50.8 (21.2) 4.56
(0.78; 8.34)
0.018
52.8 (34.0) 8.32
(1.01; 15.63)
0.026
 No 464 (64.3%) 61.8 (19.2) (ref) 14.2 (6.0) (ref) 46.3 (20.4) (ref) 44.5 (29.7) (ref)
 Yes 39 (5.4%) 51.5 (19.4) −10.24
(−17.14; −3.33)
0.004
11.9 (5.3) −2.25
(−4.20; −0.31)
0.023
60.7 (17.1) 14.42
(8.20; 20.64)
<0.001
67.2 (27.6) 22.63
(10.20; 35.06)
<0.001
Reflux therapy
 No 510 (69.2%) 61.8 (19.7) (ref) 14.3 (6.0) (ref) 46.4 (20.3) (ref) 44.5 (30.2) (ref)
 Yes 227 (30.8%) 56.1 (19.3) −5.67
(−8.99; −2.34)
0.001
12.8 (5.9) −1.53
(−2.57; −0.48)
0.004
52.7 (20.8) 6.31
(2.67; 9.94)
0.001
54.7 (32.1) 10.13
(3.45; 16.80)
0.003
  1. aDaily oral glucocorticoids; 95% CI 95% confidence interval, delta mean difference between the groups, ref. reference group, SD standard deviation
  2. bOther non-pharmacological therapy includes: flutter, physiotherapy, yoga, inhalation furosenid, breathing therapy, spinal exercise, tai chi, cardiac pacemaker