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Table 4 Association of QoL and therapy for IPF

From: Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

 

N (%)

mean (SD)

Delta 95% CI p value

mean (SD)

Delta 95% CI p value

mean (SD)

Delta 95% CI p value

mean (SD)

Delta 95% CI p value

Antiinflammatory therapya

 No

426 (57.8%)

63.6 (19.0)

(ref)

14.9 (5.9)

(ref)

43.9 (19.9)

(ref)

40.0 (27.9)

(ref)

 Yes

311 (42.2%)

55.4 (19.7)

−8.25

(−11.35; −5.15)

<0.001

12.6 (6.0)

−2.22

(−3.18; −1.25)

<0.001

53.7 (20.4)

9.84

(6.54; 13.13)

<0.001

57.6 (32.3)

17.55

(11.47; 23.62)

<0.001

Antifibrotic therapy

 No

372 (50.5%)

59.7 (20.9)

(ref)

14.0 (5.9)

(ref)

46.8 (21.7)

(ref)

46.2 (32.0)

(ref)

 Yes

365 (49.5%)

60.3 (18.4)

0.63

(−2.48; 3.74)

0.691

13.8 (6.2)

−0.19

(−1.17; 0.78)

0.698

49.9 (19.4)

3.05

(−0.29; 6.38)

0.074

49.4 (30.3)

3.13

(−3.04; 9.31)

0.319

Long-term oxygen therapy

 No

503 (68.3%)

65.8 (17.9)

(ref)

15.2 (5.7)

(ref)

42.0 (19.2)

(ref)

36.4 (27.3)

(ref)

 Yes

234 (31.8%)

47.8 (17.9)

−17.93

(−20.96; −14.90)

<0.001

11.1 (5.7)

−4.15

(−5.14; −3.17)

<0.001

61.2 (17.3)

19.18

(16.08; 22.28)

<0.001

71.2 (24.9)

34.83

(29.40; 40.25)

<0.001

Other non-pharmacological therapyb

 No

721 (97.8%)

60.3 (19.7)

(ref)

14.0 (6.0)

(ref)

48.1 (20.6)

(ref)

47.5 (31.1)

(ref)

 Yes

16 (2.2%)

49.4 (19.1)

−10.86

(−20.35; −1.37)

0.025

10.3 (6.4)

−3.71

(−6.87; −0.54)

0.022

56.3 (23.0)

8.24

(−3.55; 20.04)

0.17

66.4 (30.5)

18.98

(−2.30; 40.25)

0.08

Pulmonary rehabilitation

 Unknown

219 (30.3%)

57.7 (20.5)

−4.04

(−7.57; −0.50)

0.025

13.5 (6.3)

−0.69

(−1.80; 0.42)

0.222

50.8 (21.2)

4.56

(0.78; 8.34)

0.018

52.8 (34.0)

8.32

(1.01; 15.63)

0.026

 No

464 (64.3%)

61.8 (19.2)

(ref)

14.2 (6.0)

(ref)

46.3 (20.4)

(ref)

44.5 (29.7)

(ref)

 Yes

39 (5.4%)

51.5 (19.4)

−10.24

(−17.14; −3.33)

0.004

11.9 (5.3)

−2.25

(−4.20; −0.31)

0.023

60.7 (17.1)

14.42

(8.20; 20.64)

<0.001

67.2 (27.6)

22.63

(10.20; 35.06)

<0.001

Reflux therapy

 No

510 (69.2%)

61.8 (19.7)

(ref)

14.3 (6.0)

(ref)

46.4 (20.3)

(ref)

44.5 (30.2)

(ref)

 Yes

227 (30.8%)

56.1 (19.3)

−5.67

(−8.99; −2.34)

0.001

12.8 (5.9)

−1.53

(−2.57; −0.48)

0.004

52.7 (20.8)

6.31

(2.67; 9.94)

0.001

54.7 (32.1)

10.13

(3.45; 16.80)

0.003

  1. aDaily oral glucocorticoids; 95% CI 95% confidence interval, delta mean difference between the groups, ref. reference group, SD standard deviation
  2. bOther non-pharmacological therapy includes: flutter, physiotherapy, yoga, inhalation furosenid, breathing therapy, spinal exercise, tai chi, cardiac pacemaker