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Fig. 3 | Respiratory Research

Fig. 3

From: Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia

Fig. 3

SDF-1 Knockdown Attenuates MSC Regenerative Potential On Lung Angiogenesis. a Lung sections stained with Von Willebrand Factor (green) and 4′6-diamidino-2-phenylindole (DAPI: blue), demonstrating improved vascular density in hyperoxia-exposed pups treated with IT MSC-NS control. SDF-1 knockdown obliterated the beneficial effects of MSC on angiogenesis in experimental BPD. Original magnification X 100. Scale bars are 100 μm. b IT MSC-NS control increased vascular density in hyperoxic animals but administration of IT MSC-SDF KD reversed these beneficial effects. (*P < 0.05; normoxia vs. hyperoxia-placebo, ** P < 0.05; hyperoxia-placebo vs hyperoxia MSC-NS control, † P < 0.05; hyperoxia MSC-NS control vs. hyperoxia MSC-SDF KD; N = 5–7/group). White bars are room air (RA) and black bars are hyperoxia

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