Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Guyard, Alice; Danel, Claire; Théou-Anton, Nathalie; Debray, Marie-Pierre; Gibault, Laure; Mordant, Pierre; Castier, Yves; Crestani, Bruno; Zalcman, Gérard; Blons, Hélène; Cazes, Aurélie

doi:10.1186/s12931-017-0605-y

Table 1 Clinical features

From: Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Patient	Gender	Age (years)	Tobacco (P-Y)	Disease	CT-scan	Cancer type	Cancer location	Sampling site and mode
Idiopathic pulmonary fibrosis
P1	M	86	<5	IPF	UIP	SCC	peripheral	Lung, biopsy
P2	F	63	40	IPF	UIP	SCC	peripheral	Lung, biopsy
P3	M	60	NP	IPF	UIP	SCC	peripheral	Lung, surg. resec.
P4	M	55	40	IPF	UIP	SCC	peripheral	Lung, surg. resec.
P5	M	41	30	IPF	UIP	SCC	peripheral	Lung, biopsy
P6	M	69	45	IPF	UIP	SCC	proximal	LN, EBUS
P7	M	75	30	IPF	UIP	SCC	peripheral	Lung, surg. resec.
P8	M	66	yes (NS)	likely IPF	UIP	SCC	peripheral	Lung, surg. resec.
P9	M	68	20	IPF	UIP	ADC	peripheral	Lung, biopsy
P10	F	56	35	IPF	UIP	ADC	peripheral	Lung, biopsy
P3	M	61	NS	IPF	UIP	ADC	peripheral	Lung, autopsy
P11	M	62	0	IPF	UIP	ADC	peripheral	Pleural liquid
P12	M	58	50	IPF	UIP	ADC	peripheral	Lung, surg. resec.
P13	M	64	40	likely IPF	UIP	ADC	peripheral	Lung, surg. resec.
P14	M	73	55	IPF	UIP	ADS	proximal	Lung, surg. resec.
P15	M	67	10	IPF	UIP	ADS	peripheral	Lung, surg. resec.
P16	M	57	60	likely IPF	UIP	LCNEC	peripheral	LN, biopsy
P30	M	51	30	IPF	UIP	SmCC	peripheral	Lung, biopsy
Connective Tissue Disease-Interstitial Lung Disease
P18	M	57	40	RA	NSIP	SCC	proximal	Lung, surg. resec.
P20	F	55	10	RA	UIP	ADC	peripheral	Lung, surg. resec.
P21	M	69	100	RA	UIP	ADC	peripheral	Lung, surg. resec.
P24	M	62	40	RA	NSIP	ADS	peripheral	Lung, surg. resec.
P23	M	66	30	antisynthetase sd	NSIP	ADC	peripheral	LN, biopsy
P22	F	59	0	scleroderma	UIP	ADC	peripheral	Lung, surg. resec.
Non-specific interstitial pneumonia
P25	M	69	70	NSIP	NSIP	ADC	peripheral	Lung, surg. resec.
P26	F	54	60	NSIP	NSIP	ADC	peripheral	Lung, surg. resec.
Pneumoconiosis
P17	M	64	50	pneumoconiosis	Em-UIP	SCC	peripheral	Lung, surg. resec.
P27	M	59	17	asbestosis	UIP	ADC	peripheral	Lung, biopsy
P19	M	58	yes (NS)	Iikely asbestosis	UIP	SCC	peripheral	Lung, biopsy
P29	M	73	50	asbestosis	Em-UIP	SmCC	peripheral	Lung, biopsy
Drug-induced lung fibrosis
P28	M	87	60	NC (amiodarone?)	ILD	ADC	peripheral	Lung, biopsy

ADC adenocarcinoma, ADS adenosquamous carcinoma, EBUS endobronchial ultrasound, Em emphysema, IPF idiopathic pulmonary fibrosis, LCNEC large cell neuro-endocrine carcinoma, LN lymph node, NS not specified, NSIP non-specific interstitial pneumonia, P-Y pack-years, RA rheumatoid arthritis, SCC squamous cell carcinoma, SmCC small cell carcinoma, surg. resec surgical resection, UIP usual interstitial pneumonia

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ISSN: 1465-993X

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