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Table 1 Associations of the 1-min sit-to-stand (1-min STS) test and handgrip strength test with mortality, exacerbations and health related quality of life (HRQoL)

From: Prediction of long-term clinical outcomes using simple functional exercise performance tests in patients with COPD: a 5-year prospective cohort study

Outcome 1-min STS test (n = 371) Handgrip strength test (n = 409)
Mortality Hazard ratio (95% CI)   Hazard ratio (95% CI)
 Per 1 more rep 0.93 (0.89 to 0.97) Per 1 more kg 0.97 (0.94 to 1.00)
 Per 3 more reps 0.81 (0.65 to 0.86) Per 5 more kg 0.86 (0.73 to 1.01)
Exacerbations Incidence rate ratio (95% CI)   Incidence rate ratio (95% CI)
 Per 1 more rep 1.00 (0.99 to 1.02) Per 1 more kg 1.00 (0.98 to 1.02)
 Per 3 more reps 1.01 (0.93 to 1.09) Per 5 more kg 1.00 (0.92 to 1.08)
HRQoL Effect (95% CI)   Effect (95% CI)
CRQ dyspnoea
 Per 1 more rep 0.05 (0.03 to 0.06) Per 1 more kg 0.02 (−0.00 to 0.03)
 Per 3 more reps 0.15 (0.16 to 0.32) Per 5 more kg 0.08 (−0.00 to 0.15)
CRQ fatigue
 Per 1 more rep 0.03 (0.02 to 0.05) Per 1 more kg 0.02 (0.01 to 0.04)
 Per 3 more reps 0.10 (0.06 to 0.14) Per 5 more kg 0.12 (0.06 to 0.18)
CRQ emotional function
 Per 1 more rep 0.01 (0.00 to 0.03) Per 1 more kg 0.01 (−0.00 to 0.02)
 Per 3 more reps 0.04 (0.00 to 0.08) Per 5 more kg 0.03 (−0.02 to 0.09)
CRQ mastery
 Per 1 more rep 0.02 (0.01 to 0.03) Per 1 more kg 0.01 (−0.00 to 0.02)
 Per 3 more reps 0.05 (0.02 to 0.09) Per 5 more kg 0.04 (−0.01 to 0.10)
  1. All models were adjusted for age, sex, FEV1 L, CRQ dyspnoea and LABA/ICS, except the model with CRQ dyspnoea as the outcome, which was not adjusted for dyspnoea. The models for exacerbations were additionally adjusted for the number of exacerbations in the year before baseline. CRQ score is from 0–7, 0 = maximal impairment, 7 = no impairment.
  2. Abbreviations: 1-min STS test 1-min sit-to-stand test, rep repetition, HRQoL health-related quality of life, CRQ Chronic Respiratory Questionnaire, CI confidence interval