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Table 3 Biomarkers associated with decline in FEV1

From: Multiple biomarkers predict disease severity, progression and mortality in COPD

 

COPDGene

ECLIPSE

Biomarker(s)

β

R2m

AIC

β

R2m

AIC

None

 

0.42

1348

 

0.34

5611

CC16

−0.003

0.03

1318

0.020

0.03

5358*

SP-D

0.014

0.000003

1358

−0.013

0.08

5289

sRAGE

0.001

0.02

1315

0.016

0.04

4607

CRP

0.006

0.03

1330

0.008

0.00

5400*

Fibrinogen

0.046

0.03

1303*

0.022

0.02

5067

CC16, Fibrinogen, sRAGE

 

0.06

1268*a

 

0.07

4026*

  1. Analysis performed by linear mixed model. Covariates were age, time, gender, height, smoking status, pack years, age2, height2. The R2 reported for clinical covariates (no biomarkers) is given. The R2 reported for biomarkers refers to the R2 of the biomarkers(s) over clinical covariates alone. *p < 0.05 in a two-sided t-test for the null hypothesis that β = 0
  2. aBest model
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Respiratory Research

ISSN: 1465-993X

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