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Table 2 Biomarkers associated with severity of emphysema

From: Multiple biomarkers predict disease severity, progression and mortality in COPD

 

COPDGene

ECLIPSE

Biomarker(s)

β

Pseudo R2 CU

AIC

β

Pseudo R2 CU

AIC

None

 

0.41

1608

 

0.53

4747

CC16

−0.35

−0.0007

1609

0.26

0.05

4610

CRP

0.28

0.002

1607

−0.02

0.04

4588

SP-D

−0.696

0.004

1604*

−1.02

0.04

4583*

Fibrinogen

1.07

0.02

1582

0.16

0.13

4276

sRAGE

−1.79

0.02

1567*

−2.67

0.18

4019*

SP-D, sRAGE, CRP, Fibrinogen

 

0.04

1550*a

 

0.30

3470*

  1. Analysis performed by ordinal logistic regression. CU: Cragg & Uhler’s. Covariates were FEV1, age, smoking status, gender, race, CT scanner, and BMI. The R2 reported for clinical covariates (no biomarkers) is given. The R2 reported for biomarkers refers to the R2 of the biomarkers(s) over clinical covariates alone. *p < 10−3 in a two-sided t-test for the null hypothesis that β = 0
  2. aBest model