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Table 1 Biomarkers associated with FEV1

From: Multiple biomarkers predict disease severity, progression and mortality in COPD

 

COPDGene

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Biomarker(s)

β

R2

AIC

β

R2

AIC

CC16

13.85*

0.02

13,467*

19.77*

0.02

25,641*

SP-D

−12.03*

0.01

13,453*

−20.12*

0.03

25,635*

sRAGE

16.43*

0.02

13,332*

48.43*

0.10

22,421*

CRP

−12.27*

0.06

13,404*

−16.92*

0.09

25,205*

Fibrinogen

−47.40*

0.04

13,188*

−85.39*

0.11

23,109*

CC16, Fibrinogen, sRAGE, CRP, SP-D

 

0.13

12,951*a

 

0.24

19,148*a

  1. Analysis by linear regression. Race was the only covariate. The R2 reported for biomarkers refers to the R2 of the biomarkers(s) over clinical covariates alone. *p < 10-5 in a two-sided t-test for the null hypothesis that β = 0.
  2. aBest model