TY - JOUR AU - Burrows, B. PY - 1987 DA - 1987// TI - The natural history of asthma JO - J Allergy Clin Immunol VL - 80 UR - https://doi.org/10.1016/0091-6749(87)90052-2 DO - 10.1016/0091-6749(87)90052-2 ID - Burrows1987 ER - TY - JOUR AU - Hahn, D. L. AU - Starkey, M. R. AU - Horvat, J. C. AU - Kim, R. Y. AU - Hansbro, P. M. PY - 2010 DA - 2010// TI - Chlamydial infection and asthma: Is early allergic sensitization the only mechanism? JO - J Allergy Clin Immunol VL - 125 UR - https://doi.org/10.1016/j.jaci.2010.03.032 DO - 10.1016/j.jaci.2010.03.032 ID - Hahn2010 ER - TY - JOUR AU - Smith, D. H. AU - Malone, D. C. AU - Lawson, K. A. AU - Okamoto, L. J. AU - Battista, C. AU - Saunders, W. B. PY - 1997 DA - 1997// TI - A national estimate of the economic cost of asthma JO - Am J Resp Crit Care Med VL - 156 UR - https://doi.org/10.1164/ajrccm.156.3.9611072 DO - 10.1164/ajrccm.156.3.9611072 ID - Smith1997 ER - TY - JOUR AU - Demoly, P. AU - Gueron, B. AU - Annunziata, K. AU - Adamek, L. AU - Walters, R. D. PY - 2008 DA - 2008// TI - Update on asthma control in five European countries: results of a 2008 survey JO - Eur Respir Rev VL - 2010 ID - Demoly2008 ER - TY - JOUR AU - Schatz, M. AU - Zeiger, R. S. AU - Drane, A. AU - Harden, K. AU - Cibildak, A. AU - Oosterman, J. E. AU - Kosinski, M. PY - 2007 DA - 2007// TI - Reliability and predictive validity of the Asthma Control Test administered by telephone calls using speech recognition technology JO - J Allergy Clin Immunol VL - 119 UR - https://doi.org/10.1016/j.jaci.2006.08.042 DO - 10.1016/j.jaci.2006.08.042 ID - Schatz2007 ER - TY - JOUR AU - McIvor, R. A. AU - Boulet, L. P. AU - FitzGerald, J. M. AU - Zimmerman, S. AU - Chapman, K. R. PY - 2007 DA - 2007// TI - Asthma control in Canada: no improvement since we last looked in 1999 JO - Can Fam Physician VL - 53 ID - McIvor2007 ER - TY - JOUR AU - Webley, W. C. AU - Salva, P. S. AU - Andrzejewski, C. AU - Cirino, F. AU - West, C. A. AU - Tilahun, Y. AU - Stuart, E. S. PY - 2005 DA - 2005// TI - The bronchial lavage of pediatric patients with asthma contains infectious Chlamydia JO - Am J Respir Crit Care Med VL - 171 UR - https://doi.org/10.1164/rccm.200407-917OC DO - 10.1164/rccm.200407-917OC ID - Webley2005 ER - TY - JOUR AU - Lemanske, R. F. AU - Jackson, D. J. AU - Gangnon, R. E. AU - Evans, M. D. AU - Li, Z. AU - Shult, P. A. AU - Kirk, C. J. AU - Reisdorf, E. AU - Roberg, K. A. AU - Anderson, E. L. PY - 2005 DA - 2005// TI - Rhinovirus illnesses during infancy predict subsequent childhood wheezing JO - J Allergy Clin Immunol VL - 116 UR - https://doi.org/10.1016/j.jaci.2005.06.024 DO - 10.1016/j.jaci.2005.06.024 ID - Lemanske2005 ER - TY - JOUR AU - Wood, P. R. AU - Hill, V. L. AU - Burks, M. L. AU - Peters, J. I. AU - Singh, H. AU - Kannan, T. R. AU - Vale, S. AU - Cagle, M. P. AU - Principe, M. F. AU - Baseman, J. B. PY - 2013 DA - 2013// TI - Mycoplasma pneumoniae in children with acute and refractory asthma JO - Ann Allergy Asthma Immunol VL - 110 UR - https://doi.org/10.1016/j.anai.2013.01.022 DO - 10.1016/j.anai.2013.01.022 ID - Wood2013 ER - TY - JOUR AU - Denning, D. W. AU - O'Driscoll, B. R. AU - Hogaboam, C. M. AU - Bowyer, P. AU - Niven, R. M. PY - 2006 DA - 2006// TI - The link between fungi and severe asthmma JO - Eur Respir J VL - 27 UR - https://doi.org/10.1183/09031936.06.00074705 DO - 10.1183/09031936.06.00074705 ID - Denning2006 ER - TY - JOUR AU - Hertzen, L. C. PY - 2002 DA - 2002// TI - Role of persistent infection in the control and severity of asthma: focus on Chlamydia pneumoniae JO - Eur Respir J VL - 19 UR - https://doi.org/10.1183/09031936.02.00254402 DO - 10.1183/09031936.02.00254402 ID - Hertzen2002 ER - TY - JOUR AU - Hertzen, L. AU - Vasankari, T. AU - Liippo, K. AU - Wahlström, E. AU - Puolakkainen, M. PY - 2002 DA - 2002// TI - Chlamydia pneumoniae and severity of asthma JO - Scand J Infect Dis VL - 34 UR - https://doi.org/10.1080/00365540110077155 DO - 10.1080/00365540110077155 ID - Hertzen2002 ER - TY - JOUR AU - Cho, Y. AU - Kim, T. AU - Lee, T. AU - Moon, K. AU - Lee, J. AU - Kim, Y. AU - Lee, K. AU - Moon, H. PY - 2005 DA - 2005// TI - Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-alpha-dependent pathway JO - Clinical & Experimental Allergy VL - 35 UR - https://doi.org/10.1111/j.1365-2222.2005.02391.x DO - 10.1111/j.1365-2222.2005.02391.x ID - Cho2005 ER - TY - JOUR AU - Pearce, N. AU - Douwes, J. AU - Beasley, R. PY - 2000 DA - 2000// TI - Is allergen exposure the major primary cause of asthma? JO - Thorax VL - 55 UR - https://doi.org/10.1136/thorax.55.5.424 DO - 10.1136/thorax.55.5.424 ID - Pearce2000 ER - TY - STD TI - Thomsen SF, van der Sluis S, Kyvik KO, Backer V. A study of asthma severity in adult twins. Clin Respir J. 2011. ID - ref15 ER - TY - JOUR AU - Strachan, D. P. PY - 1989 DA - 1989// TI - Hay fever, hygiene, and household size JO - BMJ VL - 299 UR - https://doi.org/10.1136/bmj.299.6710.1259 DO - 10.1136/bmj.299.6710.1259 ID - Strachan1989 ER - TY - JOUR AU - Strachan, D. P. PY - 2000 DA - 2000// TI - Family size, infection and atopy: the first decade of the "hygiene hypothesis" JO - Thorax VL - 55 UR - https://doi.org/10.1136/thorax.55.suppl_1.S2 DO - 10.1136/thorax.55.suppl_1.S2 ID - Strachan2000 ER - TY - JOUR AU - Brooks, C. AU - Pearce, N. AU - Douwes, J. PY - 2013 DA - 2013// TI - The hygiene hypothesis in allergy and asthma: an update JO - Curr Opin Allergy Clin Immunol VL - 13 UR - https://doi.org/10.1097/ACI.0b013e32835ad0d2 DO - 10.1097/ACI.0b013e32835ad0d2 ID - Brooks2013 ER - TY - JOUR AU - Huang, Y. J. AU - Boushey, H. A. PY - 2015 DA - 2015// TI - The microbiome in asthma JO - J Allergy Clin Immunol VL - 135 UR - https://doi.org/10.1016/j.jaci.2014.11.011 DO - 10.1016/j.jaci.2014.11.011 ID - Huang2015 ER - TY - JOUR AU - Webley, W. C. AU - Hahn, D. L. PY - 2011 DA - 2011// TI - Respiratory Chlamydophyla pneumoniae resides primarily in the lower airway JO - Eur Respir J VL - 38 UR - https://doi.org/10.1183/09031936.00071711 DO - 10.1183/09031936.00071711 ID - Webley2011 ER - TY - JOUR AU - Wu, L. AU - Skinner, S. J. M. AU - Lambie, N. AU - Vuletic, J. C. AU - Blasi, F. AU - Black, P. N. PY - 2000 DA - 2000// TI - Immunohistochemical staining for Chlamydia pneumoniae is increased in lung tissue from subjects with chronic obstructive pulmonary disease JO - Am J Respir Crit Care Med VL - 162 UR - https://doi.org/10.1164/ajrccm.162.3.9912134 DO - 10.1164/ajrccm.162.3.9912134 ID - Wu2000 ER - TY - JOUR AU - Hilty, M. AU - Burke, C. AU - Pedro, H. AU - Cardenas, P. AU - Bush, A. AU - Bossley, C. AU - Davies, J. AU - Ervine, A. AU - Poulter, L. AU - Pachter, L. PY - 2010 DA - 2010// TI - Disordered microbial communities in asthmatic airways JO - PLoS One VL - 5 UR - https://doi.org/10.1371/journal.pone.0008578 DO - 10.1371/journal.pone.0008578 ID - Hilty2010 ER - TY - JOUR AU - Huang, Y. J. AU - Nelson, C. E. AU - Brodie, E. L. AU - Desantis, T. Z. AU - Baek, M. S. AU - Liu, J. AU - Woyke, T. AU - Allgaier, M. AU - Bristow, J. AU - Wiener-Kronish, J. P. PY - 2011 DA - 2011// TI - Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma JO - J Allergy Clin Immunol VL - 127 UR - https://doi.org/10.1016/j.jaci.2010.10.048 DO - 10.1016/j.jaci.2010.10.048 ID - Huang2011 ER - TY - JOUR AU - Good, J. T. AU - Rollins, D. R. AU - Martin, R. J. PY - 2012 DA - 2012// TI - Macrolides in the treatment of asthma JO - Curr Opin Pulm Med VL - 18 UR - https://doi.org/10.1097/MCP.0b013e32834daff8 DO - 10.1097/MCP.0b013e32834daff8 ID - Good2012 ER - TY - JOUR AU - Huang, Y. J. AU - Boushey, H. A. PY - 2014 DA - 2014// TI - The microbiome and asthma JO - Ann Am Thorac Soc VL - 11 UR - https://doi.org/10.1513/AnnalsATS.201306-187MG DO - 10.1513/AnnalsATS.201306-187MG ID - Huang2014 ER - TY - JOUR AU - Webley, W. C. AU - Aldridge, K. L. PY - 2015 DA - 2015// TI - Infectious asthma triggers: time to revise the hygiene hypothesis? JO - Trends Microbiol VL - 23 UR - https://doi.org/10.1016/j.tim.2015.05.006 DO - 10.1016/j.tim.2015.05.006 ID - Webley2015 ER - TY - JOUR AU - Teo, S. M. AU - Mok, D. AU - Pham, K. AU - Kusel, M. AU - Serralha, M. AU - Troy, N. AU - Holt, B. J. AU - Hales, B. J. AU - Walker, M. L. AU - Hollams, E. PY - 2015 DA - 2015// TI - The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development JO - Cell Host Microbe VL - 17 UR - https://doi.org/10.1016/j.chom.2015.03.008 DO - 10.1016/j.chom.2015.03.008 ID - Teo2015 ER - TY - JOUR AU - Shima, K. AU - Coopmeiners, J. AU - Graspeuntner, S. AU - Dalhoff, K. AU - Rupp, J. PY - 2016 DA - 2016// TI - Impact of micro-environmental changes on respiratory tract infections with intracellular bacteria JO - FEBS Lett VL - 590 UR - https://doi.org/10.1002/1873-3468.12353 DO - 10.1002/1873-3468.12353 ID - Shima2016 ER - TY - BOOK AU - Piacentini, G. L. AU - Peroni, D. G. AU - Blasi, F. AU - Pescollderungg, L. AU - Goller, P. AU - Gallmetzer, L. AU - Drago, L. PY - 2009 DA - 2009// TI - Bodini A PB - Boner AL CY - Atypical bacteria in adenoids and tonsils of children requiring adenotonsillectomy. Acta Oto-laryngologica ID - Piacentini2009 ER - TY - JOUR AU - Normann, E. AU - Gnarpe, J. AU - Nääs, J. AU - Gnarpe, H. AU - Karlsson, M. G. AU - Wettergren, B. PY - 2001 DA - 2001// TI - Chlamydia pneumoniae in children undergoing adenoidectomy JO - Acta Pediatr VL - 90 UR - https://doi.org/10.1111/j.1651-2227.2001.tb00271.x DO - 10.1111/j.1651-2227.2001.tb00271.x ID - Normann2001 ER - TY - JOUR AU - Hansbro, N. G. AU - Horvat, J. C. AU - Wark, P. A. AU - Hansbro, P. M. PY - 2008 DA - 2008// TI - Understanding the mechanisms of viral induced asthma: new therapeutic directions JO - Pharmacol Ther VL - 117 UR - https://doi.org/10.1016/j.pharmthera.2007.11.002 DO - 10.1016/j.pharmthera.2007.11.002 ID - Hansbro2008 ER - TY - JOUR AU - Johnston, S. L. AU - Pattemore, P. K. AU - Sanderson, G. AU - Smith, S. AU - Lampe, F. AU - Josephs, L. AU - Symington, P. AU - O'Toole, S. AU - Myint, S. H. AU - Tyrrell, D. A. PY - 1995 DA - 1995// TI - Community study of role of viral infections in exacerbations of asthma in 9–11 year old children JO - BMJ VL - 310 UR - https://doi.org/10.1136/bmj.310.6989.1225 DO - 10.1136/bmj.310.6989.1225 ID - Johnston1995 ER - TY - JOUR AU - Grissell, T. V. AU - Powell, H. AU - Shafren, D. R. AU - Boyle, M. J. AU - Hensley, M. J. AU - Jones, P. D. AU - Whitehead, B. F. AU - Gibson, P. G. PY - 2005 DA - 2005// TI - Interleukin-10 gene expression in acute virus-induced asthma JO - Am J Respir Crit Care Med VL - 172 UR - https://doi.org/10.1164/rccm.200412-1621OC DO - 10.1164/rccm.200412-1621OC ID - Grissell2005 ER - TY - JOUR AU - Cunningham, A. F. AU - Johnston, S. L. AU - Julious, S. A. AU - Lampe, F. C. AU - Ward, M. E. PY - 1998 DA - 1998// TI - Chronic Chlamydia pneumoniae infection and asthma exacerbations in children JO - Eur Resp J VL - 11 UR - https://doi.org/10.1183/09031936.98.11020345 DO - 10.1183/09031936.98.11020345 ID - Cunningham1998 ER - TY - JOUR AU - Hahn, D. L. AU - McDonald, R. PY - 1998 DA - 1998// TI - Can acute Chlamydia pneumoniae infection initiate chronic asthma? JO - Ann Allergy Asthma Immunol VL - 81 UR - https://doi.org/10.1016/S1081-1206(10)63126-2 DO - 10.1016/S1081-1206(10)63126-2 ID - Hahn1998 ER - TY - JOUR AU - Hahn, D. L. AU - Peeling, R. W. AU - Dillon, E. AU - McDonald, R. AU - Saikku, P. PY - 2000 DA - 2000// TI - Serologic markers for Chlamydia pneumoniae in asthma JO - Ann Allergy Asthma Immunol VL - 84 UR - https://doi.org/10.1016/S1081-1206(10)62760-3 DO - 10.1016/S1081-1206(10)62760-3 ID - Hahn2000 ER - TY - JOUR AU - Hahn, D. L. PY - 1994 DA - 1994// TI - Acute asthmatic bronchitis: A new twist to an old problem JO - J Fam Pract VL - 39 ID - Hahn1994 ER - TY - JOUR AU - Hahn, D. L. PY - 1995 DA - 1995// TI - Infectious asthma: a reemerging clinical entity? JO - J Fam Pract VL - 41 ID - Hahn1995 ER - TY - JOUR AU - Rantala, A. AU - Jaakkola, J. J. AU - Jaakkola, M. S. PY - 2011 DA - 2011// TI - Respiratory infections precede adult-onset asthma JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0027912 DO - 10.1371/journal.pone.0027912 ID - Rantala2011 ER - TY - JOUR AU - Hahn, D. L. AU - Dodge, R. AU - Golubjatnikov, R. PY - 1991 DA - 1991// TI - Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis and adult-onset asthma JO - JAMA VL - 266 UR - https://doi.org/10.1001/jama.1991.03470020051031 DO - 10.1001/jama.1991.03470020051031 ID - Hahn1991 ER - TY - JOUR AU - Hahn, D. L. PY - 1999 DA - 1999// TI - Chlamydia pneumoniae, asthma and COPD: what is the evidence? JO - Ann Allergy Asthma Immunol VL - 83 UR - https://doi.org/10.1016/S1081-1206(10)62666-X DO - 10.1016/S1081-1206(10)62666-X ID - Hahn1999 ER - TY - JOUR AU - Cook, P. J. AU - Davies, P. AU - Tunnicliffe, W. AU - Ayres, J. G. AU - Honeybourne, D. AU - Wise, R. PY - 1998 DA - 1998// TI - Chlamydia pneumoniae and asthma JO - Thorax VL - 53 UR - https://doi.org/10.1136/thx.53.4.254 DO - 10.1136/thx.53.4.254 ID - Cook1998 ER - TY - JOUR AU - Hahn, D. L. AU - Schure, A. AU - Patel, K. AU - Childs, T. AU - Drizik, E. AU - Webley, W. PY - 2012 DA - 2012// TI - Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0035945 DO - 10.1371/journal.pone.0035945 ID - Hahn2012 ER - TY - JOUR AU - Hahn, D. L. AU - Grasmick, M. AU - Hetzel, S. AU - Yale, S. PY - 2012 DA - 2012// TI - Azithromycin for bronchial asthma in adults: an effectiveness trial JO - J Am Board Fam Med VL - 25 UR - https://doi.org/10.3122/jabfm.2012.04.110309 DO - 10.3122/jabfm.2012.04.110309 ID - Hahn2012 ER - TY - CHAP AU - Hahn, D. L. ED - Friedman, H. ED - Yamamoto, Y. ED - Bendinelli, M. PY - 2004 DA - 2004// TI - Role of Chlamydia pneumoniae as an inducer of asthma BT - Chlamydia pneumoniae Infection and Disease PB - Kluwer Academic/Plenum Publishers CY - New York ID - Hahn2004 ER - TY - JOUR AU - Thomson, N. C. AU - Chaudhuri, R. AU - Livingston, E. PY - 2004 DA - 2004// TI - Asthma and cigarette smoking JO - Eur Respir J VL - 24 UR - https://doi.org/10.1183/09031936.04.00039004 DO - 10.1183/09031936.04.00039004 ID - Thomson2004 ER - TY - JOUR AU - Shemer-Avni, Y. AU - Lieberman, D. PY - 1995 DA - 1995// TI - Chlamydia pneumoniae-induced ciliostasis in ciliated bronchial epithelial cells JO - J Infect Dis VL - 171 UR - https://doi.org/10.1093/infdis/171.5.1274 DO - 10.1093/infdis/171.5.1274 ID - Shemer-Avni1995 ER - TY - CHAP AU - Hahn, D. L. ED - Johnston, S. L. ED - Papadopoulos, N. G. PY - 2003 DA - 2003// TI - Chlamydia/Mycoplasma: Do they cause new-onset asthma in adults? BT - Respiratory Infections in Allergy and Asthma PB - Marcel Dekker, Inc CY - New York ID - Hahn2003 ER - TY - JOUR AU - Patel, K. K. AU - Anderson, E. A. AU - Salva, P. S. AU - Webley, W. C. PY - 2012 DA - 2012// TI - The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms JO - Respir Res VL - 13 UR - https://doi.org/10.1186/1465-9921-13-32 DO - 10.1186/1465-9921-13-32 ID - Patel2012 ER - TY - JOUR AU - Emre, U. AU - Sokolovskaya, N. AU - Roblin, P. AU - Schacter, J. AU - Hammerschlag, M. PY - 1995 DA - 1995// TI - Detection of Chlamydia pneumoniae-IgE in children with reactive airway disease JO - J Infect Dis VL - 172 UR - https://doi.org/10.1093/infdis/172.1.265 DO - 10.1093/infdis/172.1.265 ID - Emre1995 ER - TY - JOUR AU - Yang, X. AU - HayGlass, K. T. AU - Brunham, R. C. PY - 1996 DA - 1996// TI - Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection JO - J Immunol VL - 156 ID - Yang1996 ER - TY - JOUR AU - Yang, X. AU - Gartner, J. AU - Zhu, L. AU - Wang, S. AU - Brunham, R. C. PY - 1999 DA - 1999// TI - IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection JO - J Immunol VL - 162 ID - Yang1999 ER - TY - JOUR AU - Penttila, J. M. AU - Anttila, M. AU - Puolakkainen, M. AU - Laurila, A. AU - Varkila, K. AU - Sarvas, M. AU - Makela, P. H. AU - Rautonen, N. PY - 1998 DA - 1998// TI - Local immune responses to Chlamydia pneumoniae in the lungs of BALB/c mice during primary infection and reinfection JO - Infect Immun VL - 66 ID - Penttila1998 ER - TY - JOUR AU - Stephens, R. S. PY - 2003 DA - 2003// TI - The cellular paradigm of chlamydial pathogenesis JO - Trends Microbiol VL - 11 UR - https://doi.org/10.1016/S0966-842X(02)00011-2 DO - 10.1016/S0966-842X(02)00011-2 ID - Stephens2003 ER - TY - JOUR AU - Prescott, S. L. AU - Macaubas, C. AU - Holt, B. J. AU - Smallacombe, T. B. AU - Loh, R. AU - Sly, P. D. AU - Holt, P. G. PY - 1998 DA - 1998// TI - Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile JO - J Immunol VL - 160 ID - Prescott1998 ER - TY - JOUR AU - Hansbro, P. M. AU - Beagley, K. W. AU - Horvat, J. C. AU - Gibson, P. G. PY - 2004 DA - 2004// TI - Role of atypical bacterial infection of the lung in predisposition/protection of asthma JO - Pharmacol Ther VL - 101 UR - https://doi.org/10.1016/j.pharmthera.2003.10.007 DO - 10.1016/j.pharmthera.2003.10.007 ID - Hansbro2004 ER - TY - JOUR AU - Horvat, J. C. AU - Beagley, K. W. AU - Wade, M. A. AU - Preston, J. A. AU - Hansbro, N. G. AU - Hickey, D. K. AU - Kaiko, G. E. AU - Gibson, P. G. AU - Foster, P. S. AU - Hansbro, P. M. PY - 2007 DA - 2007// TI - Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease JO - Am J Respir Crit Care Med VL - 176 UR - https://doi.org/10.1164/rccm.200607-1005OC DO - 10.1164/rccm.200607-1005OC ID - Horvat2007 ER - TY - JOUR AU - Horvat, J. C. AU - Starkey, M. R. AU - Kim, R. Y. AU - Phipps, S. AU - Gibson, P. G. AU - Beagley, K. W. AU - Foster, P. S. AU - Hansbro, P. M. PY - 2010 DA - 2010// TI - Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology JO - J Allergy Clin Immunol VL - 125 UR - https://doi.org/10.1016/j.jaci.2009.10.018 DO - 10.1016/j.jaci.2009.10.018 ID - Horvat2010 ER - TY - JOUR AU - Patel, K. K. AU - Webley, W. C. PY - 2013 DA - 2013// TI - Evidence of infectious asthma phenotype: Chlamydia-induced allergy and pathogen-specific IgE in a neonatal mouse model JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0083453 DO - 10.1371/journal.pone.0083453 ID - Patel2013 ER - TY - JOUR AU - Starkey, M. R. AU - Kim, R. Y. AU - Beckett, E. L. AU - Schilter, H. C. AU - Shim, D. AU - Essilfie, A. T. AU - Nguyen, D. H. AU - Beagley, K. W. AU - Mattes, J. AU - Mackay, C. R. PY - 2012 DA - 2012// TI - Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0042588 DO - 10.1371/journal.pone.0042588 ID - Starkey2012 ER - TY - JOUR AU - Kaiko, G. E. AU - Phipps, S. AU - Hickey, D. K. AU - Lam, C. E. AU - Hansbro, P. M. AU - Foster, P. S. AU - Beagley, K. W. PY - 2008 DA - 2008// TI - Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity JO - J Immunol VL - 180 UR - https://doi.org/10.4049/jimmunol.180.4.2225 DO - 10.4049/jimmunol.180.4.2225 ID - Kaiko2008 ER - TY - JOUR AU - Schröder, N. W. J. AU - Crother, T. M. AU - Naiki, Y. AU - Chen, S. AU - Wong, M. H. AU - Yilmaz, A. AU - Slepenkin, A. AU - Schulte, D. AU - Alsabeh, R. AU - Doherty, T. M. PY - 2008 DA - 2008// TI - Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization JO - J Allergy Clin Immunol VL - 122 UR - https://doi.org/10.1016/j.jaci.2008.06.038 DO - 10.1016/j.jaci.2008.06.038 ID - Schröder2008 ER - TY - JOUR AU - Keglowich, L. F. AU - Borger, P. PY - 2015 DA - 2015// TI - The three A's in asthma - airway smooth muscle, airway remodeling & angiogenesis JO - Open Respir Med J VL - 9 UR - https://doi.org/10.2174/1874306401509010070 DO - 10.2174/1874306401509010070 ID - Keglowich2015 ER - TY - JOUR AU - Campbell, L. A. AU - Rosenfeld, M. E. PY - 2014 DA - 2014// TI - Persistent C. pneumoniae infection in atherosclerotic lesions: rethinking the clinical trials JO - Front Cell Infect Microbiol VL - 4 UR - https://doi.org/10.3389/fcimb.2014.00034 DO - 10.3389/fcimb.2014.00034 ID - Campbell2014 ER - TY - JOUR AU - Park, C. S. AU - Lee, Y. S. AU - Kwon, H. S. AU - Lee, T. AU - Kim, T. B. AU - Moon, K. A. AU - Yoo, B. AU - Moon, H. B. AU - Cho, Y. S. PY - 2012 DA - 2012// TI - Chlamydophila pneumoniae inhibits corticosteroid-induced suppression of metalloproteinase-9 and tissue inhibitor metalloproteinase-1 secretion by human peripheral blood mononuclear cells JO - J Med Microbiol VL - 61 UR - https://doi.org/10.1099/jmm.0.036624-0 DO - 10.1099/jmm.0.036624-0 ID - Park2012 ER - TY - JOUR AU - McGrath, K. W. AU - Icitovic, N. AU - Boushey, H. A. AU - Lazarus, S. C. AU - Sutherland, E. R. AU - Chinchilli, V. M. AU - Fahy, J. V. PY - 2012 DA - 2012// TI - A large subgroup of mild-to-moderate asthma is persistently noneosinophilic JO - Am J Respir Crit Care Med VL - 185 UR - https://doi.org/10.1164/rccm.201109-1640OC DO - 10.1164/rccm.201109-1640OC ID - McGrath2012 ER - TY - JOUR AU - C-c, K. PY - 1999 DA - 1999// TI - Pathologic manifestations of chlamydial infection JO - Am Heart J VL - 138 UR - https://doi.org/10.1016/S0002-8703(99)70284-X DO - 10.1016/S0002-8703(99)70284-X ID - C-c1999 ER - TY - JOUR AU - Burrows, B. AU - Martinez, F. AU - Halonen, M. AU - Barbee, R. A. AU - Cline, M. G. PY - 1989 DA - 1989// TI - Association of asthma with serum IgE levels and skin-test reactivity to allergens JO - New Engl J Med VL - 320 UR - https://doi.org/10.1056/NEJM198902023200502 DO - 10.1056/NEJM198902023200502 ID - Burrows1989 ER - TY - BOOK AU - Hahn, D. L. PY - 2013 DA - 2013// TI - A Cure for Asthma? What Your Doctor Isn't Telling You, and Why PB - Peoples Pharmacy Press CY - Durham, North Carolina ID - Hahn2013 ER - TY - JOUR AU - Douwes, J. AU - Gibson, P. AU - Pekkanen, J. AU - Pearce, N. PY - 2002 DA - 2002// TI - Non-eosinophilic asthma: importance and possible mechanisms JO - Thorax VL - 57 UR - https://doi.org/10.1136/thorax.57.7.643 DO - 10.1136/thorax.57.7.643 ID - Douwes2002 ER - TY - JOUR AU - Simpson, J. L. AU - Powell, H. AU - Boyle, M. J. AU - Scott, R. J. AU - Gibson, P. G. PY - 2008 DA - 2008// TI - Clarithromycin targets neutrophilic airway inflammation in refractory asthma JO - Am J Respir Crit Care Med VL - 177 UR - https://doi.org/10.1164/rccm.200707-1134OC DO - 10.1164/rccm.200707-1134OC ID - Simpson2008 ER - TY - BOOK PY - 2007 DA - 2007// TI - Guidelines for the diagnosis and management of asthma ID - ref72 ER - TY - JOUR AU - Moore, W. C. AU - Bleecker, E. R. AU - Curran-Everett, D. AU - Erzurum, S. C. AU - Ameredes, B. T. AU - Bacharier, L. AU - Calhoun, W. J. AU - Castro, M. AU - Chung, K. F. AU - Clark, M. P. PY - 2007 DA - 2007// TI - Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program JO - J Allergy Clin Immunol VL - 119 UR - https://doi.org/10.1016/j.jaci.2006.11.639 DO - 10.1016/j.jaci.2006.11.639 ID - Moore2007 ER - TY - JOUR AU - Zeiger, R. S. AU - Schatz, M. AU - Chen, W. AU - Li, Q. AU - Khatry, D. B. AU - Tran, T. N. PY - 2015 DA - 2015// TI - Adherent uncontrolled adult persistent asthma: characteristics and asthma outcomes JO - J Allergy Clin Immunol Pract VL - 3 UR - https://doi.org/10.1016/j.jaip.2015.06.016 DO - 10.1016/j.jaip.2015.06.016 ID - Zeiger2015 ER - TY - JOUR AU - Zeiger, R. S. AU - Schatz, M. AU - Li, Q. AU - Chen, W. AU - Khatry, D. B. AU - Tran, T. N. PY - 2016 DA - 2016// TI - Characteristics and outcomes of HEDIS-defined asthma patients with COPD Diagnostic Coding JO - J Allergy Clin Immunol Pract VL - 4 UR - https://doi.org/10.1016/j.jaip.2015.10.002 DO - 10.1016/j.jaip.2015.10.002 ID - Zeiger2016 ER - TY - JOUR AU - Banh, H. L. PY - 2011 DA - 2011// TI - Unconventional treatment options in severe asthma: an overivew JO - J Pharm Pharm Sci VL - 14 UR - https://doi.org/10.18433/J37S36 DO - 10.18433/J37S36 ID - Banh2011 ER - TY - JOUR AU - Reiter, J. AU - Demirel, N. AU - Mendy, A. AU - Gasana, J. AU - Vieira, E. R. AU - Colin, A. A. AU - Quizon, A. AU - Forno, E. PY - 2013 DA - 2013// TI - Macrolides for the long-term management of asthma - a meta-analysis of randomized clinical trials JO - Allergy VL - 68 UR - https://doi.org/10.1111/all.12199 DO - 10.1111/all.12199 ID - Reiter2013 ER - TY - STD TI - Kew K, Undela K, Kotorts iI, Ferrara G. Macrolides for chronic asthma. Cochrane Database Syst Rev. 2015; (9): Art. No:CD002997. doi: 10.1002/14651858.CD002997.pub4. ID - ref78 ER - TY - JOUR AU - Chung, K. F. AU - Wenzel, S. E. AU - Brozek, J. L. AU - Bush, A. AU - Castro, M. AU - Sterk, P. J. AU - Adcock, I. M. AU - Bateman, E. D. AU - Bel, E. H. AU - Bleecker, E. R. PY - 2014 DA - 2014// TI - International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma JO - Eur Respir J VL - 43 UR - https://doi.org/10.1183/09031936.00202013 DO - 10.1183/09031936.00202013 ID - Chung2014 ER - TY - JOUR AU - Hahn, D. L. PY - 2009 DA - 2009// TI - Importance of evidence grading for guideline implementation: the example of asthma JO - Ann Fam Med VL - 7 UR - https://doi.org/10.1370/afm.995 DO - 10.1370/afm.995 ID - Hahn2009 ER - TY - JOUR AU - Travers, J. AU - Marsh, S. AU - Williams, M. AU - Weatherall, M. AU - Caldwell, B. AU - Shirtcliffe, P. AU - Aldington, S. AU - Beasley, R. PY - 2007 DA - 2007// TI - External validity of randomised controlled trials in asthma: to whom do the results of the trials apply? JO - Thorax VL - 62 UR - https://doi.org/10.1136/thx.2006.066837 DO - 10.1136/thx.2006.066837 ID - Travers2007 ER - TY - JOUR AU - Herland, K. AU - Akselsen, J. -. P. AU - Skjønsberg, O. H. AU - Bjermer, L. PY - 2005 DA - 2005// TI - How representative are clinical study patients with asthma or COPD for a larger "real life" population of patients with obstructive lung disease? JO - Respir Med VL - 99 UR - https://doi.org/10.1016/j.rmed.2004.03.026 DO - 10.1016/j.rmed.2004.03.026 ID - Herland2005 ER - TY - JOUR AU - Johnston, S. L. AU - Szigeti, M. AU - Cross, M. AU - Brightling, C. AU - Chaudhuri, R. AU - Harrison, T. AU - Mansur, A. AU - Robison, L. AU - Sattar, Z. AU - Jackson, D. PY - 2016 DA - 2016// TI - Azithromycin for acute exacerbations of asthma: The AZALEA randomized clinical trial JO - JAMA Intern Med VL - 176 UR - https://doi.org/10.1001/jamainternmed.2016.5664 DO - 10.1001/jamainternmed.2016.5664 ID - Johnston2016 ER - TY - JOUR AU - Brusselle, G. G. AU - Braeckel, E. PY - 2016 DA - 2016// TI - AZALEA trial highlights antibiotic overuse in acute asthma attacks JO - JAMA Intern Med VL - 176 UR - https://doi.org/10.1001/jamainternmed.2016.6046 DO - 10.1001/jamainternmed.2016.6046 ID - Brusselle2016 ER - TY - STD TI - Hahn DL. An unanticipated effect of clinical trial registration. BMJ. 2007. online at http://www.bmj.com/rapid-response/2011/11/01/unanticipated-effect-clinical-trial-registration. Accessed 16 May 2017. UR - http://www.bmj.com/rapid-response/2011/11/01/unanticipated-effect-clinical-trial-registration ID - ref85 ER - TY - JOUR AU - Cook, P. J. AU - Honeybourne, D. AU - Miles, J. F. AU - Ayres, J. G. AU - Tunnicliffe, W. AU - Phipps, J. M. AU - Treharne, J. D. AU - Wise, R. PY - 1996 DA - 1996// TI - Chlamydia pneumoniae infection is not associated with unselected cases of acute asthma, but may be associated with chronic type 1 "brittle" asthma JO - Resp Crit Care Med VL - 153 ID - Cook1996 ER - TY - JOUR AU - Hahn, D. L. AU - Plane, M. B. AU - Mahdi, O. S. AU - Byrne, G. I. PY - 2006 DA - 2006// TI - Secondary outcomes of a pilot randomized trial of azithromycin treatment for asthma JO - PLoS Clin Trials VL - 1 UR - https://doi.org/10.1371/journal.pctr.0010011 DO - 10.1371/journal.pctr.0010011 ID - Hahn2006 ER - TY - JOUR AU - Grayston, J. T. AU - Kronmal, R. A. AU - Jackson, L. A. AU - Parisis, A. F. AU - Muhlestein, J. B. AU - Cohen, J. D. AU - Rogers, W. J. AU - Crouse, J. R. AU - Borrowdale, S. R. AU - Schron, E. PY - 2005 DA - 2005// TI - Azithromycin for the secondary prevention of coronary events JO - N Engl J Med VL - 352 UR - https://doi.org/10.1056/NEJMoa043526 DO - 10.1056/NEJMoa043526 ID - Grayston2005 ER - TY - JOUR AU - O'Connor, C. M. AU - Dunne, M. W. AU - Pfeffer, M. A. AU - Muhlestein, J. P. AU - Yao, L. AU - Gupta, S. AU - Benner, R. J. AU - Fisher, M. R. AU - Cook, T. D. PY - 2003 DA - 2003// TI - Azithomycin for the secondary prevention of coronary heart disease events. The WIZARD Study: a randomized controlled trial JO - JAMA VL - 290 UR - https://doi.org/10.1001/jama.290.11.1459 DO - 10.1001/jama.290.11.1459 ID - O'Connor2003 ER - TY - JOUR AU - Albert, R. K. AU - Connett, J. AU - Bailey, W. C. AU - Casaburi, R. AU - Cooper, J. A. AU - Criner, G. J. AU - Curtis, J. L. AU - Dransfield, M. T. AU - Han, M. K. AU - Lazarus, S. C. PY - 2011 DA - 2011// TI - Azithromycin for prevention of exacerbations of COPD JO - N Engl J Med VL - 365 UR - https://doi.org/10.1056/NEJMoa1104623 DO - 10.1056/NEJMoa1104623 ID - Albert2011 ER - TY - JOUR AU - Ray, W. A. AU - Murray, K. T. AU - Hall, K. AU - Arbogast, P. G. AU - Stein, C. M. PY - 2012 DA - 2012// TI - Azithromycin and the risk of cardiovascular death JO - N Engl J Med VL - 366 UR - https://doi.org/10.1056/NEJMoa1003833 DO - 10.1056/NEJMoa1003833 ID - Ray2012 ER - TY - JOUR AU - Svanstrom, H. AU - Pasternak, B. AU - Hviid, A. PY - 2013 DA - 2013// TI - Use of azithromycin and death from cardiovascular causes JO - N Engl J Med VL - 368 UR - https://doi.org/10.1056/NEJMoa1300799 DO - 10.1056/NEJMoa1300799 ID - Svanstrom2013 ER - TY - JOUR AU - Khosropour, C. M. AU - Capizzi, J. D. AU - Schafer, S. D. AU - Kent, J. B. AU - Dombrowski, J. C. AU - Golden, M. R. PY - 2014 DA - 2014// TI - Lack of association between azithromycin and death from cardiovascular causes JO - N Engl J Med VL - 370 UR - https://doi.org/10.1056/NEJMc1401831 DO - 10.1056/NEJMc1401831 ID - Khosropour2014 ER - TY - JOUR AU - Wenzel, R. P. AU - Fowler, A. A. AU - Edmond, M. B. PY - 2012 DA - 2012// TI - Antibiotic prevention of acute exacerbations of COPD JO - N Engl J Med VL - 367 UR - https://doi.org/10.1056/NEJMct1115170 DO - 10.1056/NEJMct1115170 ID - Wenzel2012 ER - TY - JOUR AU - Segal, L. N. AU - Clemente, J. C. AU - Wu, B. G. AU - Wikoff, W. R. AU - Gao, Z. AU - Li, Y. AU - Ko, J. P. AU - Rom, W. N. AU - Blaser, M. J. AU - Weiden, M. D. PY - 2017 DA - 2017// TI - Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung JO - Thorax VL - 72 UR - https://doi.org/10.1136/thoraxjnl-2016-208599 DO - 10.1136/thoraxjnl-2016-208599 ID - Segal2017 ER - TY - JOUR AU - Slater, M. AU - Rivett, D. W. AU - Williams, L. AU - Martin, M. AU - Harrison, T. AU - Sayers, I. AU - Bruce, K. D. AU - Shaw, D. PY - 2014 DA - 2014// TI - The impact of azithromycin therapy on the airway microbiota in asthma JO - Thorax VL - 69 UR - https://doi.org/10.1136/thoraxjnl-2013-204517 DO - 10.1136/thoraxjnl-2013-204517 ID - Slater2014 ER - TY - JOUR AU - Carr, T. F. AU - Kraft, M. PY - 2016 DA - 2016// TI - Chronic infection and severe asthma JO - Immunol Allergy Clin North Am VL - 36 UR - https://doi.org/10.1016/j.iac.2016.03.010 DO - 10.1016/j.iac.2016.03.010 ID - Carr2016 ER - TY - JOUR AU - Loudon, K. AU - Treweek, S. AU - Sullivan, F. AU - Donnan, P. AU - Thorpe, K. E. AU - Zwarenstein, M. PY - 2015 DA - 2015// TI - The PRECIS-2 tool: designing trials that are fit for purpose JO - BMJ VL - 350 UR - https://doi.org/10.1136/bmj.h2147 DO - 10.1136/bmj.h2147 ID - Loudon2015 ER - TY - JOUR AU - Wong, E. H. AU - Porter, J. D. AU - Edwards, M. R. AU - Johnston, S. L. PY - 2014 DA - 2014// TI - The role of macrolides in asthma: current evidence and future directions JO - Lancet Respir Med VL - 2 UR - https://doi.org/10.1016/S2213-2600(14)70107-9 DO - 10.1016/S2213-2600(14)70107-9 ID - Wong2014 ER - TY - JOUR AU - Juniper, E. F. AU - Guyatt, G. H. AU - Ferrie, P. J. AU - Griffith, L. E. PY - 1993 DA - 1993// TI - Measuring quality of life in asthma JO - Am Rev Respir Dis VL - 147 UR - https://doi.org/10.1164/ajrccm/147.4.832 DO - 10.1164/ajrccm/147.4.832 ID - Juniper1993 ER - TY - BOOK AU - Suresh Babu, K. PY - 2013 DA - 2013// TI - Kastelik J PB - Morjaria JB CY - Role of long term antibiotics in chronic respiratory diseases. Respir Med ID - Suresh Babu2013 ER - TY - JOUR AU - Spagnolo, P. AU - Fabbri, L. M. AU - Bush, A. PY - 2013 DA - 2013// TI - Long-term macrolide treatment for chronic respiratory disease JO - Eur Respir J VL - 42 UR - https://doi.org/10.1183/09031936.00136712 DO - 10.1183/09031936.00136712 ID - Spagnolo2013 ER - TY - STD TI - Krishnan JA. Rofumilast or azithromycin to prevent COPD exacerbations (RELIANCE). http://www.pcori.org/research-results/2016/roflumilast-or-azithromycin-prevent-copd-exacerbations-reliance. Accessed 16 May 2017. UR - http://www.pcori.org/research-results/2016/roflumilast-or-azithromycin-prevent-copd-exacerbations-reliance ID - ref103 ER - TY - JOUR AU - Rollins, D. R. AU - Good, J. T. AU - Martin, R. J. PY - 2014 DA - 2014// TI - The role of atypical infections and macrolide therapy in patients with asthma JO - J Allergy Clin Immunol Pract VL - 2 UR - https://doi.org/10.1016/j.jaip.2014.06.002 DO - 10.1016/j.jaip.2014.06.002 ID - Rollins2014 ER -