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Table 2 Remodelling and immunohistological findings

From: Immunohistology and remodeling in fatal pediatric and adolescent asthma

  Fatal asthma cases Healthy controls p*
RBM, um [median, (IQR)]a 5,7 (2,8) 2,3 (1,3) 0.001
RBM, um [median, (IQR)]b 5,3 (1,8) 3,4 (0,8) 0.002
ASM large AW, %, [median, (IQR)] 15,1 (15,6) 15 (3,5) 0.933
ASM small AW, % [median, (IQR)] 14,0 (7) 14,0 (8) 0.553
T cells [median, (IQR)] 197 (159) 213/126) 0.866
B cells [median, (IQR)] 43 (95) 19,3 (18) 0.028
Macrophages [median, (IQR)] 216 (110) 93 (22) 0.001
Mast cells [median, (IQR)] 73 (23) 75 (220) 0.8
CD15 + cells [median, (IQR)] 53 (187) 65 (130) 0.671
Eosinophils [median, (IQR)] 120 (220) 0 (4) <0.001
Plasmacytoid dendritic cells, [median, (IQR)] 20 (30) 4 (10) 0.012
Mucus bronchi [median, (IQR)] 2 (1) 1 (1) <0.001
Mucus bronchioles [median, (IQR)] 1 (0) 0 (0) <0.001
Outer luminal diameter, large AW, mm [median, (IQR)] 2,0 (1,1) 1,5 (0,8) 0.069
Inner luminal diameter, large AW, mm [median, (IQR)] 1,0 (0,4) 0,9 (0,4) 0.353
Wall thickness, large AW, mm [median, (IQR)] 0,9 (0,9) 0,7 (0,4) 0.103
Luminal diameter, small AW, mm [median, (IQR)] 0,3 (0,1) 0,2 (0,1) 0.472
  1. Abbrevations: RBM reticular basement membrane, IQR interquartile range, ASM airway smooth muscle, AW airways
  2. *Mann Whitney’s test for continuous variables
  3. All the bolded p-values are of significance (they are < 0.05)
  4. aPerpendicular method
  5. bGrid overlay method