Table 2 Remodelling and immunohistological findings
From: Immunohistology and remodeling in fatal pediatric and adolescent asthma
Fatal asthma cases | Healthy controls | p* | |
|---|---|---|---|
RBM, um [median, (IQR)]a | 5,7 (2,8) | 2,3 (1,3) | 0.001 |
RBM, um [median, (IQR)]b | 5,3 (1,8) | 3,4 (0,8) | 0.002 |
ASM large AW, %, [median, (IQR)] | 15,1 (15,6) | 15 (3,5) | 0.933 |
ASM small AW, % [median, (IQR)] | 14,0 (7) | 14,0 (8) | 0.553 |
T cells [median, (IQR)] | 197 (159) | 213/126) | 0.866 |
B cells [median, (IQR)] | 43 (95) | 19,3 (18) | 0.028 |
Macrophages [median, (IQR)] | 216 (110) | 93 (22) | 0.001 |
Mast cells [median, (IQR)] | 73 (23) | 75 (220) | 0.8 |
CD15 + cells [median, (IQR)] | 53 (187) | 65 (130) | 0.671 |
Eosinophils [median, (IQR)] | 120 (220) | 0 (4) | <0.001 |
Plasmacytoid dendritic cells, [median, (IQR)] | 20 (30) | 4 (10) | 0.012 |
Mucus bronchi [median, (IQR)] | 2 (1) | 1 (1) | <0.001 |
Mucus bronchioles [median, (IQR)] | 1 (0) | 0 (0) | <0.001 |
Outer luminal diameter, large AW, mm [median, (IQR)] | 2,0 (1,1) | 1,5 (0,8) | 0.069 |
Inner luminal diameter, large AW, mm [median, (IQR)] | 1,0 (0,4) | 0,9 (0,4) | 0.353 |
Wall thickness, large AW, mm [median, (IQR)] | 0,9 (0,9) | 0,7 (0,4) | 0.103 |
Luminal diameter, small AW, mm [median, (IQR)] | 0,3 (0,1) | 0,2 (0,1) | 0.472 |