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Table 2 Differences and similarities in clinical features between sputum eosinophilhigh and AC patients

From: Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma

  AC
n = 14
Sputum Eosinophilhigh subgroup
n = 24
p value
Gender (% Male) 79 75 >0.99
Age (years) 57.0 (6.9) 68.3 (7.9) <0.0001
BMI (kg/m2) 29.1 (4.5) 27.1 (4.5) 0.19
FFMI(kg/m2) 16.8 (2.7) 17.2 (3.7) 0.70
Smoking history (% Ex) 71 58 0.51
Pack years 33.7 [13.5–69.8] 46.3 [16.8–154.0] 0.06
Exacerbation (12mths prior) 3 [0–5] 1 [0–5] 0.02
Chronic bronchitis (%) 86 71 0.44
Any comorbidities (%) 85 79 >0.99
Age COPD diagnosis 50.7 (5.9) 62.7 (7.7) <0.0001
Duration of COPD diagnosis (years) 8 [0.5–16.0] 5.5 [2.0–17.0] 0.71
ICS use (%) 93 79 0.38
ICS dose (BDP equivalent) 1550 [0–2000] 1000 [0–2000] 0.60
SGRQ total 34.0 [15.3–78.8] 51.5 [6.0–90.5] 0.34
CAT 19.3 (8.8) 18.9 (9.9) 0.90
CCQ total 1.8 [0.6–5.1] 2.5 [0.5–4.7] 0.74
Skin prick positive to >1 allergen (%) 50 0 0.0003
Allergic rhinitis (%) 0 8.7 0.52
Hayfever (%) 57.1 12.5 0.008
Eczema (%) 35.7 25.0 0.71
Yes to do you suffer from allergies? (%) 85.7 8.3 <0.0001
Family history of asthma (%) 53.8 36.4 0.48
Total IgE (IU/ml) 156 [2–2458] 69.5 [2–1868] 0.30
High IgE (>100 IU/ml) 50.0 71.4 0.74
Pre FEV1 (L) 1.8 (0.7) 1.2 (0.4) 0.003
Pre FEV1 (%) 55.3 (16.6) 44.8 (14.4) 0.048
Pre FEV1/FVC 0.5 (0.1) 0.3 (0.1) <0.001
Post FEV1 (L) 2.0 (0.7) 1.3 (0.4) 0.003
Post FEV1 (%) 61.5 (16.5) 51.0 (14.1) 0.04
Post FEV1/FVC 0.5 (0.1) 0.4 (0.1) <0.001
Reversibility % 8.1 [-4.9–30.4] 15.7 [0–48.2] 0.15
Reversibility (ml) 175.0 [-100.0–510.0] 125.0 [-60.0–400.0] 0.87
BDR ≥12% and 200ml (%) 28.6 37.5 0.73
BDR ≥15% and 400ml (%) 14.3 4.2 0.54
Raw (kPa.sec) 0.4 (0.2) 0.6 (0.2) 0.11
sGaw (kPa.sec) 0.4 [0.2–1.1] 0.4 [0.1–1.2] 0.30
VC % 89.8 [77.9–111.5] 88.9 [65.8–129.5] 0.60
TLC% 106.9 (16.4) 112.3 (17.0) 0.38
RV % 145.3 (51.7) 151.1 (64.5) 0.79
IC % 82.1 (14.0) 67.4 (12.3) 0.004
FRC % 125.5 (26.5) 138.9 (48.5) 0.37
KCO % 79.2 (13.3) 75.6 (19.8) 0.56
6MWD (metres) 376.4 (73.8) 330.4 (95.1) 0.16
FeNO 50 (ppb) 11.3 [5.2–56.0] 14.3 [7.0–40.3] 0.25
Blood eosinophil count (109/L) 0.22 [0.10–0.53] 0.25 [0.06–1.14] 0.37
Blood eosinophil % 3.5 [0.9–7.8] 3.4 [0.9–20.7] 0.97
Blood eosinophil >5% 14.3 25.0 0.68
Blood eosinophil count ≥300 cells/μl 35.7 41.7 >0.99
Sputum total cell count ×106/g 3.3 [1.0–21.2] 5.9 [0.5–33.0] 0.04
Sputum neutrophil % 68.8 [27.5–91] 77.8 [48.0–92.0] 0.14
Sputum macrophage % 21.2[6.8–44.0] 14.8 [1.2–32.3] 0.03
Sputum eosinophil % 2.5 [0.5–9.3] 6.0 [3.2–16.3] 0.0004
Sputum lymphocyte % 0.3 [0.0–4.5] 0.0 [0.0–1.0] 0.06
Sputum epithelial cells % 2.8 [0.3–27.5] 1.0 [0.0–13.0] 0.08
Sputum neutrophil cell count ×106/g 2.5 [0.3–17.5] 4.7 [0.3–29.4] 0.04
Sputum macrophage cell count ×106/g 0.6 [0.2–2.1] 0.6 [0.1–3.9] 0.67
Sputum eosinophil cell count ×106/g 0.1 [0.01–1.3] 0.04 [0.02–1.3] 0.001
Sputum lymphocyte cell count ×106/g 0.01 [0.0–0.06] 0.0 [0.0–0.17] 0.29
Sputum epithelial cell count ×106/g 0.2 [0.0–0.9] 0.07 [0.0–0.89] 0.08
Sputum eosinophil ≥3% 46.2 100 0.0002
Bacterial load (genome copies/ml) 4.97×104 [0.00–2.06×106] 5.52×104 [0.00–1.24×107] 0.66
Colonised (sum bacterial load ≥1×104) (%) 83 67 0.44
  1. Data is presented as mean (SD), medians [range] or % as appropriate; spirometry values were related to the reference values of the European Community for Coal and Steel (ECCS)
  2. Definitions of abbreviations: AC COPD with childhood asthma diagnosis, ICS Inhaled corticosteroids, BDP Beclometasone disproportionate, BMI Body Mass Index, FFMI Fat Free Mass Index, BDR Bronchodilator response, Raw Airway resistance, sGAW specific conductance, SGRQ St George’s Respiratory Questionnaire, CCQ Clinical COPD Questionnaire, CAT COPD Assessment Test, Pre Pre bronchodilator, Post Post bronchodilator, FEV 1 Forced Expired Volume in first second, FVC Forced vital capacity, VC Vital Capacity, TLC Total Lung Capacity, RV Residual Volume, IC Inspiratory Capacity, FRC Functional Residual Capacity, KCO Carbon monoxide transfer coefficient, 6MWD 6 minute walk distance, FeNO 50 Fractional exhaled nitric oxide at 50ml/sec flow rate
  3. The bold p values represent significant p values