Variable | Discovery | Replication | P-value* | ||
---|---|---|---|---|---|
N | 238 COPD | 323 COPD | 58 controls | ||
Age | 64.2 ± 6.2 | 63.9 ± 6.1 | 59.6 ± 6.5 | <0.001 | |
Male | 64.3% | 67.8% | 62.1% | 0.556 | |
BMI | 28.1 ± 6 | 26.5 ± 5.8 | 28.6 ± 4.3 | 0.001 | |
Smoker | <0.001 | ||||
Former | 96.6% | 54.5% | 53.4% | ||
Current | 3.4% | 45.5% | 0% | ||
Never | 0% | 0% | 46.6% | ||
Pack years | 46 ± 26.9 | 48.2 ± 26.4 | 26.9 ± 14.1 | <0.001 | |
FEV1% predicted | 49.5 ± 16.2 | 49.7 ± 15.9 | 109.7 ± 15.8 | <0.001 | |
FEV1/FVC | 0.46 ± 0.13 | 0.45 ± 0.11 | 0.79 ± 0.06 | <0.001 | |
GOLD | -- | ||||
2 | 43.7% | 39.6% | -- | ||
3 | 44.1% | 49.2% | -- | ||
4 | 12.2% | 11.1% | -- | ||
Exacerbations in prior year | 1.6 ± 1.8 | 0.4 ± 0.5 | -- | <0.001 |