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Fig. 9 | Respiratory Research

Fig. 9

From: Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

Fig. 9

Effect of FK866 on NF-κB activation and Akt phosphorylation in lung tissues. FK866 reduced Akt phosphorylation (a) and nuclear NF-κB p65 levels (b), and increased IκB-α levels (c) in ischemia-reperfusion (IR)-induced lung injury. PCNA and β-actin served as loading controls for nuclear and cytoplasmic proteins, respectively. Representative blots are shown. Data are expressed as mean ± SD (n = 6 per group). *p < 0.05, ***p < 0.001, compared with the control group; ++ p < 0.01, +++ p < 0.001, compared with the IR group

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