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Fig. 8 | Respiratory Research

Fig. 8

From: Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

Fig. 8

Effect of FK866 on MAPK and MKP-1 expressions in lung tissue. The phosphorylation of ERK (a), JNK (b), and p38 (c) was enhanced in the ischemia-reperfusion (IR) group. FK866 treatment attenuated these effects. In contrast, the expression of MKP-1 protein (d) was decreased in the IR group but reversed by FK866 treatment. β-actin served as the loading control. A representative blot is shown. All data are shown as mean ± SD (n = 6 per group). *p < 0.05, ***p < 0.001, compared with the control group; + p < 0.05, ++ p < 0.01, compared with the IR group

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