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Fig. 7 | Respiratory Research

Fig. 7

From: Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats

Fig. 7

Effect of FK866 on the expression of caspase-3 and Bcl-2 in lung tissue. a Immunohistochemistry for active caspase-3 in the lung (indicated with an arrowhead) (200× magnification). b Western blot analysis of Bcl-2 protein in the lung tissue. β-actin served as a loading control for cytoplasmic proteins. Representative blots are shown. Ischemia-reperfusion (IR) significantly decreased Bcl-2 protein expression and induced caspase-3 activation in the lung tissue. FK866 treatment significantly increased Bcl-2 protein expression and attenuated the signals for active caspase-3 in the IR group. Representative blots are shown. Data are expressed as mean ± SD (n = 6 per group). ***p < 0.01, compared with the control group; +++ p < 0.01, compared with the IR group

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