Fig. 10

Effect of FK866 on A549 cells subjected to hypoxia-reoxygenation (H/R). a A representative Western blot of NF-κB nuclear translocation in the lung tissue. β-actin served as the loading control. FK866 significantly reduced the increase of degradation of IκB-α (b), phosphorylated NF-κB p65 (c) at 2 h and 4 h, and IL-8 production (d) at 4 h in A549 cells exposed to H/R. Data are expressed as mean ± SD (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001 compared with the control group. ⁺ p < 0.05, ⁺⁺⁺ p < 0.001, compared with the H/R group