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Table 1 Respiratory mechanics at start (H0) and after a 5-h (H5) of low tidal volume mechanical ventilation (MV) following a lipopolysaccharide (LPS) or vehicle (saline) aspiration in wild type (WT) and interleukin-6 knock-out (IL-6KO) mice, receiving either recombinant human interleukin-6 (rHuIL-6) or vehicle (saline)

From: Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury

  WT(MV) WT(LPS+MV) WT + rHuIL-6(LPS+MV) IL-6KO(MV) IL-6KO(LPS+MV) IL-6KO + rHuIL-6(LPS+MV)
Peak Pr H0 post-VHS 10.5 [10.3–11.0] 11.6 [11.3–12.0] 12.0 [11.6–12.5] 10.7 [10.1–10.9] 11.6 [11.3–12.4] 12.0 [11.4–13.6]
Peak Pr H5 17.7 [16.3–18.3] 21.5 [20.5–22.0] 22.6 [22.3–23.5] 17.3 [15.6–18.5] 21.3 [20.0–22.5] 20.9 [20.6–22.4]
Cstat H0 pre-VHS 96 [93–106] 67 [54–73] 65 [58–69] 92 [82–99] 51 [47–62] 54 [49–62]
Cstat H0 post-VHS 108 [106–112] 80 [65–88] 78 [70–83] 101 [97–103] 60 [56–65] 64 [57–68]
Cstat H5 82 [75–82] 49 [41–54] 43 [38–50] 78 [71–92] 41 [38–47] 43 [42–50]
Cdyn H0 pre-VHS 32 [30–35] 22 [18–25] 24 [23–26] 31 [27–35] 23 [20–27] 26 [22–28]
Cdyn H0 post-VHS 53 [49–57] 32 [30–36] 34 [30–36] 53 [49–54] 32 [27–40] 35 [31–37]
Cdyn H5 21 [19–23] 13 [12–14] 13 [11–14] 22 [19–28] 12 [12–14] 15 [13–15]
Edyn H0 pre-VHS 31 [29–33] 45 [40–55] 44 [39–46] 33 [29–37] 43 [37–49] 39 [37–46]
Edyn H0 post-VHS 19 [18–20] 32 [28–33] 30 [29–33] 19 [19–21] 32 [25–37] 29 [27–33]
Edyn H5 48 [45–53] 78 [72–86] 75 [72–90] 47 [36–52] 82 [71–85] 68 [67–75]
  1. Data are presented as median [25th–75th percentile]
  2. Abbreviations: Peak Pr peak inspiratory pressures, Cstat quasi-static compliance of the respiratory system (calculated using a pressure-volume curve), Cdyn dynamic compliance of the respiratory system (calculated using the single frequency forced oscillation technique), Edyn dynamic elastance of the respiratory system (calculated using the single frequency forced oscillation technique). Volume history standardization (VHS) consisted in two inflations to an airway pressure of 30 cmH2O. N = 8 to 10 animals per group