Table 1 Respiratory mechanics at start (H0) and after a 5-h (H5) of low tidal volume mechanical ventilation (MV) following a lipopolysaccharide (LPS) or vehicle (saline) aspiration in wild type (WT) and interleukin-6 knock-out (IL-6KO) mice, receiving either recombinant human interleukin-6 (rHuIL-6) or vehicle (saline)
|  | WT(MV) | WT(LPS+MV) | WT + rHuIL-6(LPS+MV) | IL-6KO(MV) | IL-6KO(LPS+MV) | IL-6KO + rHuIL-6(LPS+MV) |
|---|---|---|---|---|---|---|
Peak Pr H0 post-VHS | 10.5 [10.3–11.0] | 11.6 [11.3–12.0] | 12.0 [11.6–12.5] | 10.7 [10.1–10.9] | 11.6 [11.3–12.4] | 12.0 [11.4–13.6] |
Peak Pr H5 | 17.7 [16.3–18.3] | 21.5 [20.5–22.0] | 22.6 [22.3–23.5] | 17.3 [15.6–18.5] | 21.3 [20.0–22.5] | 20.9 [20.6–22.4] |
Cstat H0 pre-VHS | 96 [93–106] | 67 [54–73] | 65 [58–69] | 92 [82–99] | 51 [47–62] | 54 [49–62] |
Cstat H0 post-VHS | 108 [106–112] | 80 [65–88] | 78 [70–83] | 101 [97–103] | 60 [56–65] | 64 [57–68] |
Cstat H5 | 82 [75–82] | 49 [41–54] | 43 [38–50] | 78 [71–92] | 41 [38–47] | 43 [42–50] |
Cdyn H0 pre-VHS | 32 [30–35] | 22 [18–25] | 24 [23–26] | 31 [27–35] | 23 [20–27] | 26 [22–28] |
Cdyn H0 post-VHS | 53 [49–57] | 32 [30–36] | 34 [30–36] | 53 [49–54] | 32 [27–40] | 35 [31–37] |
Cdyn H5 | 21 [19–23] | 13 [12–14] | 13 [11–14] | 22 [19–28] | 12 [12–14] | 15 [13–15] |
Edyn H0 pre-VHS | 31 [29–33] | 45 [40–55] | 44 [39–46] | 33 [29–37] | 43 [37–49] | 39 [37–46] |
Edyn H0 post-VHS | 19 [18–20] | 32 [28–33] | 30 [29–33] | 19 [19–21] | 32 [25–37] | 29 [27–33] |
Edyn H5 | 48 [45–53] | 78 [72–86] | 75 [72–90] | 47 [36–52] | 82 [71–85] | 68 [67–75] |