Fig. 7

Hemodynamic data obtained during hypoxic challenges. WT mice received either recombinant human interleukin-6 (rHuIL-6) or rHuIL-6 in association with the non-specific inhibitor of nitric oxide synthase Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). Control mice received vehicle (saline). Five hours later, mice were intubated for mechanical ventilation and an ultra-miniature catheter was immediately inserted into the right jugular vein and advanced into the right ventricle. a After 30 min of stabilization, the right ventricular systolic pressure was continuously recorded during four consecutive hypoxic challenges (FiO2 of 0.08 during 2 min, followed by 5 min of reoxygenation). Points represent the mean and errors bars represent the standard error of the mean. b The delta of right ventricular systolic pressure was calculated as the mean difference from peak to baseline right ventricular systolic pressure during the four consecutive hypoxic challenges. The symbol * denotes Benjamini-Hochberg corrected p value < 0.05 of the Mann–Whitney pairwise comparisons (following Kruskal Wallis test). Columns represent the mean and error bars represent the standard error of the mean. N = 4 animals per group