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Fig. 6 | Respiratory Research

Fig. 6

From: Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury

Fig. 6

Hemodynamic data obtained at the end of a 5-h low tidal volume mechanical ventilation (MV) following either a lipopolysaccharide (LPS) or vehicle (saline) aspiration in wild type (WT) and interleukin-6 knock-out (IL-6KO) mice receiving either recombinant human interleukin-6 (rHuIL-6) or vehicle (saline). a Right ventricular systolic pressure (mmHg). b Total pulmonary resistances (mmHg.min/mL). c Heart rate (bpm). Right ventricular systolic pressure was measured during a short end-expiratory pause using an ultra-miniature catheter inserted into the right jugular vein and advanced into the right ventricle. Cardiac output was measured by the transpulmonary thermodilution technique. Total pulmonary resistances were calculated as the ratio of right ventricular systolic pressure to cardiac output (measured by the transpulmonary thermodilution technique). The symbol * denotes Benjamini-Hochberg corrected p value < 0.05 of Mann–Whitney pairwise comparisons (following Kruskal Wallis test). Data are presented as box and whiskers plots. N = 6 to 8 animals per group

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