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Fig. 2 | Respiratory Research

Fig. 2

From: Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury

Fig. 2

Respiratory mechanics during 5-h (H0 to H5) low tidal volume mechanical ventilation (MV) following either lipopolysaccharide (LPS) or vehicle (saline) aspiration in wild type (WT) and interleukin-6 knock-out (IL-6KO) mice receiving either recombinant human interleukin-6 (rHuIL-6) or vehicle (saline). The following respiratory system properties are shown A. Peak inspiratory pressures. B. Quasi-static compliance of the respiratory system calculated using a pressure-volume curve. C. Dynamic compliance of the respiratory system calculated using the single frequency forced oscillation technique. D. Dynamic elastance of the respiratory system calculated using the single frequency forced oscillation technique. Volume history standardization (VHS) consisted in two inflations to an airway pressure of 30 cmH2O. The letters a, b, c, d, e, f, g, h and i denote Benjamini-Hochberg corrected p values <0.05 of Mann-Whitney pairwise comparisons (following Kruskal Wallis test): WT(MV) vs. WT(LPS+MV), WT(MV) vs. WT + rHuIL-6(LPS+MV), WT(LPS+MV) vs. WT + rHuIL-6(LPS+MV), IL-6KO(MV) vs. IL-6KO(LPS+MV), IL-6KO(MV) vs. IL-6KO + rHuIL-6(LPS+MV), IL-6KO(LPS+MV) vs. IL-6KO + rHuIL-6(LPS+MV), WT(MV) vs. IL-6KO(MV), WT(LPS+MV) vs. IL-6KO(LPS+MV) and WT + rHuIL-6(LPS+MV) vs. IL-6KOrHuIL-6(LPS+MV) respectively. Data are presented as mean and standard error of the mean. N = 8 to 10 animals per group

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