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Table 3 Pulmonary function variables over time and telomere length rate of change in COPD patients

From: Telomere shortening and accelerated aging in COPD: findings from the BODE cohort

Variable High rate of shorteningb
(n = 35)
Low rate of shortening maintenance or lengtheningc
(n = 35)
  Baseline 3-years p-value Baseline 3-years p-value
FEV1 (L) 1.66 ± 0.72 1.59 ± 0.68 0.04 1.60 ± 0.5 1.52 ± 0.5 0.15
FEV1(%pred) 59 ± 20 58 ± 20 0.63 59 ± 19 58 ± 19 0.54
FVC (L) 3.01 ± 0.99 2.95 ± 0.98 0.35 3.15 ± 0.94 3.01 ± 0.97 0.12
FEV1/FVC 54 ± 10 53 ± 11 0.21 52 ± 12 52 ± 13 0.77
PaO2 (mmHg) 73.5 ± 7.9 70.9 ± 9.6 0.04 72.1 ± 12.9 68.8 ± 11.6 0.09
KCO (%)a 77.3 ± 23.7 74.9 ± 23.4 0.21 74.4 ± 19.1 70.6 ± 20.4 0.16
IC/TLC (%) 35 ± 9 31 ± 10 0.03 36 ± 8 32 ± 8 0.02
  1. Data are presented as mean ± SD and were compared by Paired Sample T-Test. FEV 1 forced expiratory volume in one second, FVC forced vital capacity, % pred per cent predicted, PaO 2 partial oxygen tension, K CO diffusion capacity of carbon monoxide, IC/TLC inspiratory to total lung capacity ratio. aSubjects consider to analysis in each group (n = 17). bBelow the median of telomere length rate of change. cUpper the median telomere length rate of change