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Table 2 Pulmonary function characteristics of the three groups of patients with COPD defined by their baseline telomere length

From: Telomere shortening and accelerated aging in COPD: findings from the BODE cohort

Variable

Short T/Sa

(n = 40)

Medium T/Sa

(n = 41)

Long T/Sa

(n = 40)

p-value

T/S ratiob

0.44 ± 0.09

0.66 ± 0.07

1.09 ± 0.21

<0.001

Sex (male%)

65

66

67

N.S.

Age (years)b

59 ± 7

58 ± 8

55 ± 9

N.S.

BMI (Kg/m2)b

28 ± 6

27 ± 5

27 ± 5

N.S.

Smoking habitd

(pack-yrs)bd

62 ± 28

63 ± 24

57 ± 23

N.S.

Active smoking (%)

42

56

52

N.S.

FEV1 (L)b

1.70 ± 0.71

1.64 ± 0.67

1.66 ± 0.74

N.S.

FEV1 (% pred)b

61 ± 23

59 ± 21

58 ± 21

N.S.

FVC (% pred)b

89 ± 24

92 ± 22

87 ± 21

N.S.

FEV1 / FVC (%)b

55 ± 12

51 ± 13

53 ± 12

N.S.

PaO2 (mmHg)b

71.1 ± 15.7

71.9 ± 15.8

73.5 ± 11.5

N.S.

Kco (%)

74.1 ± 25.6

75.5 ± 24.1

75.2 ± 21.1

N.S.

IC/TLC (%)

37 ± 6

36 ± 8

35 ± 10

N.S.

6MWD (m)b

517 ± 77

537 ± 95

513 ± 92

N.S.

mMRC dyspneac

1 (0–2)

1 (0–2)

1 (0–2)

N.S.

BODE indexc

1 (0–2)

1 (0–3)

1 (0–3)

N.S.

Charlson indexc

0 (0–1)

0 (0–1)

0 (0–1)

N.S.

  1. aGroups defined by telomere length (T/S) tertiles: <0.54, 0.54–0.73 and >0.73. Data are presented as bmean ± SD and cmedian (25th-75thpc) and compared by ANOVA test or Chi2 test. dNumber of packs of cigarettes smoked per day x number of years smoking. BMI body mass index, T/S ratio relative telomere length, FEV 1 forced expiratory volume in one second, FVC forced vital capacity, % pred per cent predicted. PaO 2 partial oxygen tension, K CO diffusion capacity of carbon monoxide, IC/TLC inspiratory to total lung capacity ratio, 6MWD six-min walk distance test. N.S non-significant