Skip to main content

Table 2 Pulmonary function characteristics of the three groups of patients with COPD defined by their baseline telomere length

From: Telomere shortening and accelerated aging in COPD: findings from the BODE cohort

Variable Short T/Sa
(n = 40)
Medium T/Sa
(n = 41)
Long T/Sa
(n = 40)
p-value
T/S ratiob 0.44 ± 0.09 0.66 ± 0.07 1.09 ± 0.21 <0.001
Sex (male%) 65 66 67 N.S.
Age (years)b 59 ± 7 58 ± 8 55 ± 9 N.S.
BMI (Kg/m2)b 28 ± 6 27 ± 5 27 ± 5 N.S.
Smoking habitd
(pack-yrs)bd
62 ± 28 63 ± 24 57 ± 23 N.S.
Active smoking (%) 42 56 52 N.S.
FEV1 (L)b 1.70 ± 0.71 1.64 ± 0.67 1.66 ± 0.74 N.S.
FEV1 (% pred)b 61 ± 23 59 ± 21 58 ± 21 N.S.
FVC (% pred)b 89 ± 24 92 ± 22 87 ± 21 N.S.
FEV1 / FVC (%)b 55 ± 12 51 ± 13 53 ± 12 N.S.
PaO2 (mmHg)b 71.1 ± 15.7 71.9 ± 15.8 73.5 ± 11.5 N.S.
Kco (%) 74.1 ± 25.6 75.5 ± 24.1 75.2 ± 21.1 N.S.
IC/TLC (%) 37 ± 6 36 ± 8 35 ± 10 N.S.
6MWD (m)b 517 ± 77 537 ± 95 513 ± 92 N.S.
mMRC dyspneac 1 (0–2) 1 (0–2) 1 (0–2) N.S.
BODE indexc 1 (0–2) 1 (0–3) 1 (0–3) N.S.
Charlson indexc 0 (0–1) 0 (0–1) 0 (0–1) N.S.
  1. aGroups defined by telomere length (T/S) tertiles: <0.54, 0.54–0.73 and >0.73. Data are presented as bmean ± SD and cmedian (25th-75thpc) and compared by ANOVA test or Chi2 test. dNumber of packs of cigarettes smoked per day x number of years smoking. BMI body mass index, T/S ratio relative telomere length, FEV 1 forced expiratory volume in one second, FVC forced vital capacity, % pred per cent predicted. PaO 2 partial oxygen tension, K CO diffusion capacity of carbon monoxide, IC/TLC inspiratory to total lung capacity ratio, 6MWD six-min walk distance test. N.S non-significant