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Table 1 Role of migration‐associated biomolecules in lung and vascular diseases

From: The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration

Name Role Diseases References
c‐Abl Tyrosine kinase, promote migration Asthma, PAH, atherosclerosis [12, 98, 106, 107, 111]
β‐catenin Junction protein, collective migration Asthma [104]
Cortactin Adapter protein, promote protrusion Asthma [103]
FAK Tyrosine kinase, adhesion, signaling Vascular injury [110]
Integrin β1 Mechanoreceptor, adhesion, signaling Asthma, vascular injury [102, 110]
mDia1 Actin‐associated protein, actin nucleation Vascular Injury [112]
Myosin Contractile protein Vascular injury [97, 110]
p38MAPK S/T kinase, promote locomotion Asthma [1, 99]
Pfn‐1 Actin‐associated protein, migration Hypertension [108]
PI3K‐γ Kinase, regulate actin and microtubules Asthma [105]
RhoA/ROCK S/T kinase, promote contraction Asthma [100, 101]
Vimentin IF protein, promote contraction/motility Vascular remodeling [109]
  1. FAK foca adhesion kinase, IF intermediate filament, Pfn‐1 profilin‐1, PAH pulmonary arterial hypertension, S/T serine/threonine, ROCK Rho kinase