The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration

Table 1 Role of migration‐associated biomolecules in lung and vascular diseases

Name	Role	Diseases	References
c‐Abl	Tyrosine kinase, promote migration	Asthma, PAH, atherosclerosis	[12, 98, 106, 107, 111]
β‐catenin	Junction protein, collective migration	Asthma	[104]
Cortactin	Adapter protein, promote protrusion	Asthma	[103]
FAK	Tyrosine kinase, adhesion, signaling	Vascular injury	[110]
Integrin β1	Mechanoreceptor, adhesion, signaling	Asthma, vascular injury	[102, 110]
mDia1	Actin‐associated protein, actin nucleation	Vascular Injury	[112]
Myosin	Contractile protein	Vascular injury	[97, 110]
p38MAPK	S/T kinase, promote locomotion	Asthma	[1, 99]
Pfn‐1	Actin‐associated protein, migration	Hypertension	[108]
PI3K‐γ	Kinase, regulate actin and microtubules	Asthma	[105]
RhoA/ROCK	S/T kinase, promote contraction	Asthma	[100, 101]
Vimentin	IF protein, promote contraction/motility	Vascular remodeling	[109]

FAK foca adhesion kinase, IF intermediate filament, Pfn‐1 profilin‐1, PAH pulmonary arterial hypertension, S/T serine/threonine, ROCK Rho kinase

ISSN: 1465-993X