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Fig. 3 | Respiratory Research

Fig. 3

From: The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration

Fig. 3

Regulation of airway smooth muscle cell migration by c-Abl tyrosine kinase. c-Abl is recruited to the leading edge by integrin β1, which activates the downstream pathways and regulates actin cytoskeletal remodeling in lamellipodia. Abi1, Abl interactor 1; Arp2/3, Actin-related protein 2/3; CAS, CrkII-associated substrate; GMF-γ, glia maturation factor-γ; N-WASP, neuronal Wiskott-Aldrich Syndrome Protein; Pfn-1, profilin-1

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